Visible-Light-Induced Defluorinative α-C(sp)-H Alkylation for the Synthesis of -Difluoroallylated α-Trifluoromethylamines.

Herein, we describe a novel and efficient photoredox catalytic C radical addition/defluoroalkylation coupling reaction between α-trifluoromethyl alkenes and -trifluoroethyl hydroxylamine. A series of -difluoroallylated α-trifluoromethylamines were synthesized by the C radical addition enabled by a 1,2-H shift of the in situ-generated trifluoroethyl radical. Notably, this protocol is distinguished by its mild conditions, easy operation, and excellent functional group tolerability.