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一名9岁转移性颈动脉体副神经节瘤患儿对177镥-奥曲肽肽受体放射性核素治疗完全缓解

Complete Response to 177 Lu-DOTATATE PRRT in a 9-Year-Old Child With Metastatic Carotid Body Paraganglioma.

作者信息

Yadav Madhav Prasad, Raju Shobhana, Ballal Sanjana, Bal Chandrasekhar

机构信息

From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Clin Nucl Med. 2024 Jan 1;49(1):e33-e34. doi: 10.1097/RLU.0000000000004929. Epub 2023 Nov 16.

Abstract

We present a case involving a 9-year-old boy diagnosed with metastatic carotid body paraganglioma. The metastases were detected in cervical lymph nodes and lungs using 68 Ga-DOTANOC PET/CT imaging. The patient received peptide receptor radionuclide therapy with 177 Lu-DOTATATE. Following 3 treatment cycles, a significant improvement was observed in the metastatic lesions. After 4 cycles, the patient achieved a complete response, with a cumulative administered activity of 16.65 GBq during the therapy. This case underscores the effectiveness of using 177 Lu-DOTATATE in managing metastatic carotid body paraganglioma, offering promising results in terms of tumor regression and overall therapeutic response.

摘要

我们报告了一例9岁男孩被诊断为转移性颈动脉体副神经节瘤的病例。使用68 Ga-DOTANOC PET/CT成像在颈部淋巴结和肺部检测到转移灶。该患者接受了177 Lu-DOTATATE肽受体放射性核素治疗。经过3个治疗周期后,转移病灶有显著改善。4个周期后,患者达到完全缓解,治疗期间累积给药活度为16.65 GBq。该病例强调了使用177 Lu-DOTATATE治疗转移性颈动脉体副神经节瘤的有效性,在肿瘤消退和总体治疗反应方面提供了有希望的结果。

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