Department of Physical Medicine and Rehabilitation, Burke Rehabilitation Hospital, White Plains, NY.
Department of Physical Medicine & Rehabilitation, Montefiore Medical Center, Bronx, NY.
Pain Physician. 2023 Nov;26(7):569-574.
Radiofrequency ablation (RFA) is a common treatment in which radiofrequency (RF) is used to heat neural tissue and reduce pain. The impact of adipose content in tissue on the lesion size may impact efficacy, and to date, there is little, if any, data comparing its influence on RFA.
We evaluated the influence of adipose tissue on RF lesion size.
Controlled, ex vivo study.
Academic institution in a procedural setting.
RF lesions were created using 20-G 10-mm protruding electrode (PE) needles inserted into unbrined chicken breasts and thighs at 21°C. RF current was applied for 90 seconds at 80°C. Chicken breasts were used as the control group and chicken thighs were used as the high adipose variant. Four different groups were examined: 1- Standard 20 g RFA needle, 2- 20 g RFA PE needle, 3- Standard RFA needle with lidocaine 2% injectate, and 4- Standard RFA needle with iohexol 240 mg injectate. There were 12 lesions performed in each group; length, width, and depth were measured.
The control group had significantly deeper lesions in all 4 cohorts. Lesions' lengths were smaller in the fat-rich group. The control and PE cohorts showed a significant difference in width between the 2 fat-rich and nonfatty groups.
Radiofrequency ablation was performed at room temperature and not heated to physiological temperature. This was an ex vivo study, thus factors of human anatomy and physiology could not be evaluated.
Adipose tissue content was inversely related to lesion size in all samples. This factor should be considered when assessing methods of enhancing lesion size in human models.
射频消融（RFA）是一种常见的治疗方法，它利用射频（RF）加热神经组织以减轻疼痛。组织中的脂肪含量对病变大小的影响可能会影响疗效，迄今为止，关于其对 RFA 影响的数据很少，如果有的话。
我们评估了脂肪组织对 RF 病变大小的影响。
对照、离体研究。
程序环境中的学术机构。
在 21°C 下，将 20-G 10-mm 突出电极（PE）针插入未腌制的鸡胸肉和鸡腿中，创建 RF 病变。以 80°C 施加 90 秒 RF 电流。鸡胸肉用作对照组，鸡腿用作高脂肪变异组。检查了 4 个不同的组：1-标准 20 g RFA 针，2-20 g RFA PE 针，3-标准 RFA 针加 2%利多卡因注射液，4-标准 RFA 针加 240mg 碘海醇注射液。每组进行了 12 个病变；测量长度、宽度和深度。
在所有 4 个队列中，对照组的病变深度明显更深。富含脂肪的组中的病变长度较小。在富含脂肪和非脂肪组之间，控制组和 PE 组的宽度存在显着差异。
射频消融在室温下进行，而不是加热至生理温度。这是一项离体研究，因此无法评估人体解剖学和生理学的因素。
在所有样本中，脂肪组织含量与病变大小呈负相关。在评估人体模型中增强病变大小的方法时，应考虑此因素。
