Oreland L, Gottfries C G
Prog Neuropsychopharmacol Biol Psychiatry. 1986;10(3-5):533-40. doi: 10.1016/0278-5846(86)90023-0.
Brain MAO-B activity increases with age. The rate of increase varies in different brain regions. Brain MAO-A activity does not change with age in man and is decreased in the rat. Brain MAO-B activity in AD/SDAT is higher than in age-matched controls. The increased MAO-B activity in aging is due to an increased concentration of otherwise unchanged extrasynaptosomal MAO-B. The increase in brain MAO-B activity with age and in AD/SDAT is more pronounced in white matter than in gray matter. Platelet MAO is increased in patients with AD/SDAT.
脑单胺氧化酶B（MAO-B）活性随年龄增长而增加。不同脑区的增加速率有所不同。在人类中，脑单胺氧化酶A（MAO-A）活性不随年龄变化，而在大鼠中则降低。阿尔茨海默病/老年期痴呆（AD/SDAT）患者的脑MAO-B活性高于年龄匹配的对照组。衰老过程中MAO-B活性增加是由于突触外MAO-B浓度增加，而其本身未发生变化。随着年龄增长以及在AD/SDAT中，脑MAO-B活性在白质中的增加比在灰质中更明显。AD/SDAT患者的血小板MAO增加。
