Sparks D L, Woeltz V M, Markesbery W R
Department of Pathology, University of Kentucky Medical Center, Lexington 40536-0230.
Arch Neurol. 1991 Jul;48(7):718-21. doi: 10.1001/archneur.1991.00530190064017.
Alzheimer's disease (AD) and Pick's disease (PD) are dementing disorders of unknown origin. Monoamine oxidase (MAO) is important in the metabolism of a number of monoamine neurotransmitters. This study investigates MAO activity in aging, AD, and PD in frontal and temporal poles, nucleus basalis of Meynert (nbM), and hypothalamus. Regional variations in the activity of the two MAO forms (A and B) were found in aging, AD, and PD. Age-related increase of MAO-B was found in all four areas of the brain, and MAO-A was increased in the nbM and temporal pole. In AD, MAO-B was decreased in the nbM and increased in the temporal pole, while MAO-A was increased in the hypothalamus and frontal pole. In PD, MAO-B was decreased in the nbM and increased in the hypothalamus, while MAO-A was increased in the hypothalamus and decreased in the nbM and temporal pole. These data indicate that with regard to MAO activity, AD and PD are dissimilar diseases and neither strictly follows age-related changes.
阿尔茨海默病（AD）和匹克病（PD）是病因不明的痴呆症。单胺氧化酶（MAO）在多种单胺神经递质的代谢中起重要作用。本研究调查了额叶和颞叶、迈内特基底核（nbM）及下丘脑在衰老、AD和PD中的MAO活性。在衰老、AD和PD中发现了两种MAO形式（A和B）活性的区域差异。在大脑的所有四个区域均发现与年龄相关的MAO-B增加，而在nbM和颞叶中MAO-A增加。在AD中，nbM中的MAO-B降低，颞叶中的MAO-B增加，而下丘脑中的MAO-A增加，额叶中的MAO-A增加。在PD中，nbM中的MAO-B降低，下丘脑中的MAO-B增加，而下丘脑中的MAO-A增加，nbM和颞叶中的MAO-A降低。这些数据表明，就MAO活性而言，AD和PD是不同的疾病，两者均未严格遵循与年龄相关的变化。
