Parnetti L, Reboldi G P, Santucci C, Santucci A, Gaiti A, Brunetti M, Cecchetti R, Senin U
Dipartimento di Medicina Clinica, University of Perugia, Italy.
Aging (Milano). 1994 Jun;6(3):201-7. doi: 10.1007/BF03324240.
Both low and high platelet MAO-B (pMAO-B) activity is considered an indicator of increased vulnerability in psychopathology. How the activity of this peripheral enzyme can be linked with the sophisticated functions of the central nervous system (CNS) is not clear; in man, evidence exists that the genetic mechanisms determining the size or capacity of the central serotonin system are common to platelet and brain MAO. In the present study pMAO-B activity was evaluated in demented patients suffering from early-onset Alzheimer's disease (AD), late-onset Alzheimer's disease (SDAT), vascular dementia (VD), and controls. In these dementia categories, the relationship between pMAO-B activity and clinical features, and between pMAO-B activity and cerebrospinal fluid (CSF) monoamine metabolites (3-methoxy-4-hydroxyphenyl-glycol, MHPG; 5-hydroxy-indoleacetic acid, 5-HIAA; homovanillic acid, HVA) was also investigated. pMAO-B activity was significantly higher in SDAT patients, compared to controls and AD. Age, as covariate, failed to show any significant effect, and no association was found between pMAO-B activity and CSF monoamine metabolites. The correlation analysis between pMAO-B and neuropsychological scores showed a highly significant positive relationship with GBS-emotional impairment (N = 40, r = 0.72, p < 0.01) in the SDAT group. This result suggests the importance of platelet MAO-B activity as biological marker also in old-age dementias, namely senile dementia of Alzheimer type, where the increased activity of this enzyme might constitute a marker for vulnerability toward behavioural disturbance, i.e., emotional deterioration.
血小板单胺氧化酶 - B（pMAO - B）活性无论是低还是高，都被视为精神病理学中易感性增加的一个指标。这种外周酶的活性如何与中枢神经系统（CNS）的复杂功能相联系尚不清楚；在人类中，有证据表明，决定中枢5 - 羟色胺系统大小或容量的遗传机制在血小板和脑单胺氧化酶中是相同的。在本研究中，对患有早发性阿尔茨海默病（AD）、晚发性阿尔茨海默病（SDAT）、血管性痴呆（VD）的痴呆患者以及对照组进行了pMAO - B活性评估。在这些痴呆类型中，还研究了pMAO - B活性与临床特征之间的关系，以及pMAO - B活性与脑脊液（CSF）单胺代谢产物（3 - 甲氧基 - 4 - 羟基苯乙二醇，MHPG；5 - 羟基吲哚乙酸，5 - HIAA；高香草酸，HVA）之间的关系。与对照组和AD患者相比，SDAT患者的pMAO - B活性显著更高。作为协变量的年龄未显示出任何显著影响，并且未发现pMAO - B活性与CSF单胺代谢产物之间存在关联。pMAO - B与神经心理学评分之间的相关性分析显示，在SDAT组中，pMAO - B与GBS情绪障碍之间存在高度显著的正相关（N = 40，r = 0.72，p < 0.01）。该结果表明，血小板MAO - B活性作为生物学标志物在老年痴呆中也很重要，即在阿尔茨海默型老年痴呆中，这种酶活性的增加可能构成行为障碍（即情绪恶化）易感性的一个标志物。
