Department of Geriatrics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China.
Department of Nursing, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China.
Biomed Pharmacother. 2023 Dec 31;169:115839. doi: 10.1016/j.biopha.2023.115839. Epub 2023 Nov 15.
Copper-induced cell death, also known as cuproptosis, is distinct from other types of cell death such as apoptosis, necrosis, and ferroptosis. It can trigger the accumulation of lethal reactive oxygen species, leading to the onset and progression of aging. The significant increases in copper ion levels in the aging populations confirm a close relationship between copper homeostasis and vascular aging. On the other hand, vascular aging is also closely related to the occurrence of various cardiovascular diseases throughout the aging process. However, the specific causes of vascular aging are not clear, and different living environments and stress patterns can lead to individualized vascular aging. By exploring the correlations between copper-induced cell death and vascular aging, we can gain a novel perspective on the pathogenesis of vascular aging and enhance the prognosis of atherosclerosis. This article aims to provide a comprehensive review of the impacts of copper homeostasis on vascular aging, including their effects on endothelial cells, smooth muscle cells, oxidative stress, ferroptosis, intestinal flora, and other related factors. Furthermore, we intend to discuss potential strategies involving cuproptosis and provide new insights for copper-related vascular aging.
铜诱导的细胞死亡，也称为铜死亡，与细胞凋亡、坏死和铁死亡等其他类型的细胞死亡不同。它可以引发致命活性氧的积累，导致衰老的发生和进展。衰老人群中铜离子水平的显著增加证实了铜动态平衡与血管衰老之间的密切关系。另一方面，血管衰老也与衰老过程中各种心血管疾病的发生密切相关。然而，血管衰老的确切原因尚不清楚，不同的生活环境和应激模式会导致个体的血管衰老。通过探索铜诱导的细胞死亡与血管衰老之间的相关性，我们可以从新的角度了解血管衰老的发病机制，并增强动脉粥样硬化的预后。本文旨在全面综述铜动态平衡对血管衰老的影响，包括其对内皮细胞、平滑肌细胞、氧化应激、铁死亡、肠道菌群等相关因素的影响。此外，我们还将讨论涉及铜死亡的潜在策略，并为铜相关的血管衰老提供新的见解。
