Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, IL 60612, USA.
Department of Biological Sciences, University of Illinois Chicago, Chicago, IL 60607, USA.
Cell Chem Biol. 2023 Nov 16;30(11):1337-1339. doi: 10.1016/j.chembiol.2023.10.015.
Optimizing pharmacokinetic properties remains challenging but is generally guided by a set of structural rules. However, no such rule set exists for intracellular distribution. Kilgore et al. have examined small molecule partitioning within biomolecular condensates, yielding findings that could open a new window in the drug design and discovery process.
优化药代动力学性质仍然具有挑战性，但通常可以通过一组结构规则来指导。然而，对于细胞内分布，目前还没有这样的规则集。Kilgore 等人研究了小分子在生物分子凝聚物中的分配情况，得出的发现可能为药物设计和发现过程开辟新的窗口。
