Vázquez C M, Bolufer J, Murillo M L
Rev Esp Fisiol. 1986 Sep;42(3):289-94.
The effect of 50% or 80% distal enteroctomy on cholesterol and bile salt levels in male Wistar rats have been investigated. Short time measurements showed that serum cholesterol levels were maximal after 20 days from 50% intestinal resection and after 10 days from 80% intestinal resection. This increase was maintained in 50% resected rats 1 and 5 months after operation, whilts in 80% resected group the values became normal. Portal blood and bile cholesterol levels remain almost normal except 5 months after 50% intestinal resection. Bile salt concentration and bile salt output in the bile decrease after 1 and 5 months from 50% intestinal resection and after 1 month from 80% intestinal resection. These results together with data of fecal loss of bile salts indicate that in 50% resected rats new steady states have been reached, with low levels of bile salts in the bile. One month after 80% resection the fecal loss of bile salts was so high that the conversion of cholesterol into bile salts was increased. After 5 months from 80% resection values in serum and bile were almost normal suggesting either an increase in extrahepatic cholesterol synthesis or a partial prevention of fecal loss that can be explained by the observed caecal enlargement.
研究了50%或80%远端肠切除术对雄性Wistar大鼠胆固醇和胆汁盐水平的影响。短期测量显示，50%肠切除术后20天和80%肠切除术后10天血清胆固醇水平最高。这种升高在50%切除的大鼠术后1个月和5个月时仍保持，而在80%切除的组中数值恢复正常。除了50%肠切除术后5个月外，门静脉血和胆汁胆固醇水平几乎保持正常。50%肠切除术后1个月和5个月以及80%肠切除术后1个月，胆汁中的胆汁盐浓度和胆汁盐输出量降低。这些结果与胆汁盐粪便流失数据一起表明，在50%切除的大鼠中已达到新的稳态，胆汁中胆汁盐水平较低。80%切除术后1个月，胆汁盐的粪便流失量非常高，以至于胆固醇向胆汁盐的转化增加。80%切除术后5个月，血清和胆汁中的数值几乎正常，这表明要么肝外胆固醇合成增加，要么可以用观察到的盲肠增大来解释粪便流失的部分预防。
