Rush Alzheimer's Disease Center, USA; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.
Rush Alzheimer's Disease Center, USA; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA; Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL, USA.
Neurobiol Aging. 2024 Feb;134:21-27. doi: 10.1016/j.neurobiolaging.2023.11.003. Epub 2023 Nov 8.
At autopsy, African American decedents often have mixed Alzheimer's and cerebrovascular brain pathologies including arteriolosclerosis. We applied a novel in-vivo classifier of ARTerioloSclerosis (ARTS) in 167 older African Americans (∼75y of age) with > 2 biennial 3 T MRI scans and > 3 years of associated cognitive follow-up to determine if ARTS scores (higher score=higher likelihood of arteriolosclerosis) changed over time and if this change associated with changes in cognition in the same individuals. Mixed effects regression models tested whether ARTS scores increased over time, while simultaneous mixed effects regression models estimated the simultaneous rates of change in both ARTS and cognition and the correlation of these changes. ARTS scores increased over time (estimate=0.030, SE=0.002, p < 0.0001). Faster increases in ARTS were associated with faster rates of global cognitive decline (r = -0.447, p = 0.006) and domain-specific cognitive functions. Applying an in-vivo marker of arteriolosclerosis in an African American cohort revealed that the likelihood of arteriolosclerosis increases over time, and participants whose ARTS scores increased more rapidly tended to have faster than average rates of cognitive decline.
在尸检中，非裔美国人的死者通常同时存在阿尔茨海默病和脑血管性脑病理学，包括小动脉硬化。我们在 167 名年龄在 75 岁以上的老年非裔美国人中应用了一种新的动脉粥样硬化活体分类器（ARTS），这些人有超过 2 次两年一次的 3T MRI 扫描和超过 3 年的相关认知随访，以确定 ARTS 评分（分数越高，动脉粥样硬化的可能性越大）是否随时间变化，以及这种变化是否与同一人群认知的变化相关。混合效应回归模型检验了 ARTS 评分是否随时间增加，而同时的混合效应回归模型则估计了 ARTS 和认知同时变化的速度以及这些变化的相关性。ARTS 评分随时间增加（估计值=0.030，SE=0.002，p<0.0001）。ARTS 评分增加较快与整体认知下降速度较快（r=-0.447，p=0.006）和特定认知功能领域有关。在非裔美国人队列中应用动脉粥样硬化的活体标志物表明，动脉粥样硬化的可能性随时间增加，ARTS 评分增加较快的参与者往往比平均认知下降速度更快。
