Dickie Erin W, Ameis Stephanie H, Boileau Isabelle, Diaconescu Andreea O, Felsky Daniel, Goldstein Benjamin I, Gonçalves Vanessa, Griffiths John D, Haltigan John D, Husain Muhammad O, Rubin-Kahana Dafna S, Iftikhar Myera, Jani Melanie, Lai Meng-Chuan, Lin Hsiang-Yuan, MacIntosh Bradley J, Wheeler Anne L, Vasdev Neil, Vieira Erica, Ahmadzadeh Ghazaleh, Heyland Lindsay, Mohan Akshay, Ogunsanya Feyi, Oliver Lindsay D, Zhu Cherrie, Wong Jimmy K Y, Charlton Colleen, Truong Jennifer, Yu Lujia, Kelly Rachel, Cleverley Kristin, Courtney Darren B, Foussias George, Hawke Lisa D, Hill Sean, Kozloff Nicole, Polillo Alexia, Rotenberg Martin, Quilty Lena C, Tempelaar Wanda, Wang Wei, Nikolova Yuliya S, Voineskos Aristotle N
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Mar;9(3):275-284. doi: 10.1016/j.bpsc.2023.10.013. Epub 2023 Nov 17.
The Toronto Adolescent and Youth (TAY) Cohort Study will characterize the neurobiological trajectories of psychosis spectrum symptoms, functioning, and suicidality (i.e., suicidal thoughts and behaviors) in youth seeking mental health care. Here, we present the neuroimaging and biosample component of the protocol. We also present feasibility and quality control metrics for the baseline sample collected thus far.
The current study includes youths (ages 11-24 years) who were referred to child and youth mental health services within a large tertiary care center in Toronto, Ontario, Canada, with target recruitment of 1500 participants. Participants were offered the opportunity to provide any or all of the following: 1) 1-hour magnetic resonance imaging (MRI) scan (electroencephalography if ineligible for or declined MRI), 2) blood sample for genomic and proteomic data (or saliva if blood collection was declined or not feasible) and urine sample, and 3) heart rate recording to assess respiratory sinus arrhythmia.
Of the first 417 participants who consented to participate between May 4, 2021, and February 2, 2023, 412 agreed to participate in the imaging and biosample protocol. Of these, 334 completed imaging, 341 provided a biosample, 338 completed respiratory sinus arrhythmia, and 316 completed all 3. Following quality control, data usability was high (MRI: T1-weighted 99%, diffusion-weighted imaging 99%, arterial spin labeling 90%, resting-state functional MRI 95%, task functional MRI 90%; electroencephalography: 83%; respiratory sinus arrhythmia: 99%).
The high consent rates, good completion rates, and high data usability reported here demonstrate the feasibility of collecting and using brain imaging and biosamples in a large clinical cohort of youths seeking mental health care.
多伦多青少年和青年（TAY）队列研究将对寻求心理健康护理的青年中精神病谱系症状、功能和自杀倾向（即自杀念头和行为）的神经生物学轨迹进行特征描述。在此，我们介绍该方案的神经影像学和生物样本部分。我们还展示了迄今为止收集的基线样本的可行性和质量控制指标。
本研究纳入了加拿大安大略省多伦多市一家大型三级护理中心内被转介至儿童和青少年心理健康服务机构的青年（11至24岁），目标招募1500名参与者。参与者有机会提供以下任何一项或全部：1）1小时的磁共振成像（MRI）扫描（若不符合MRI条件或拒绝MRI，则进行脑电图检查），2）用于基因组和蛋白质组数据的血液样本（若拒绝或无法采集血液，则为唾液样本）以及尿液样本，3）心率记录以评估呼吸性窦性心律不齐。
在2021年5月4日至2023年2月2日期间同意参与的前417名参与者中，412人同意参与成像和生物样本方案。其中，334人完成了成像，341人提供了生物样本，338人完成了呼吸性窦性心律不齐评估，316人完成了所有三项。经过质量控制，数据可用性较高（MRI：T1加权像99%，扩散加权成像99%，动脉自旋标记90%，静息态功能MRI 95%，任务功能MRI 90%；脑电图：83%；呼吸性窦性心律不齐：99%）。
此处报告的高同意率、良好的完成率和高数据可用性证明了在寻求心理健康护理的大量青年临床队列中收集和使用脑成像及生物样本的可行性。
