Lane Fox Clinical Respiratory Physiology Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Centre for Human and Applied Physiological Sciences (CHAPS), King's College London, London, UK.
Thorax. 2024 Feb 15;79(3):281-288. doi: 10.1136/thorax-2023-220035.
Chronic respiratory disease can exacerbate the normal physiological changes in ventilation observed in healthy individuals during sleep, leading to sleep-disordered breathing, nocturnal hypoventilation, sleep disruption and chronic respiratory failure. Therefore, patients with obesity, slowly and rapidly progressive neuromuscular disease and chronic obstructive airways disease report poor sleep quality. Non-invasive ventilation (NIV) is a complex intervention used to treat sleep-disordered breathing and nocturnal hypoventilation with overnight physiological studies demonstrating improvement in sleep-disordered breathing and nocturnal hypoventilation, and clinical trials demonstrating improved outcomes for patients. However, the impact on subjective and objective sleep quality is dependent on the tools used to measure sleep quality and the patient population. As home NIV becomes more commonly used, there is a need to conduct studies focused on sleep quality, and the relationship between sleep quality and health-related quality of life, in all patient groups, in order to allow the clinician to provide clear patient-centred information.
慢性呼吸系统疾病可使健康个体在睡眠中通气的正常生理变化恶化，导致睡眠呼吸障碍、夜间通气不足、睡眠中断和慢性呼吸衰竭。因此，肥胖症、进行性缓慢或快速的神经肌肉疾病以及慢性气道疾病患者报告睡眠质量差。无创通气（NIV）是一种用于治疗睡眠呼吸障碍和夜间通气不足的复杂干预措施，夜间生理研究显示其可改善睡眠呼吸障碍和夜间通气不足，临床试验显示患者的结局得到改善。然而，对主观和客观睡眠质量的影响取决于用于测量睡眠质量的工具和患者人群。随着家庭 NIV 的应用越来越普遍，有必要针对所有患者群体开展侧重于睡眠质量以及睡眠质量与健康相关生活质量之间关系的研究，以便临床医生能够提供以患者为中心的明确信息。
