• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Rapid chemical synthesis and circular dichroism properties of some 2'-5'-linked oligoriboadenylates.某些2'-5'-连接的寡聚腺苷酸的快速化学合成及圆二色性特性
Nucleic Acids Res. 1979 Jun 11;6(7):2569-82. doi: 10.1093/nar/6.7.2569.
2
Synthesis and properties of 5'-triphosphoryl 2'-5' oligoadenylates (2-5A), and a general method for synthesis of 3', 5'-bisphosphorylated oligonucleotides.5'-三磷酸化2'-5'寡腺苷酸（2-5A）的合成与性质，以及3',5'-双磷酸化寡核苷酸的通用合成方法。
Nucleic Acids Res. 1981 Apr 24;9(8):2003-20. doi: 10.1093/nar/9.8.2003.
3
Chemical synthesis of 5'-pyrophosphate and triphosphate derivatives of 3'-5' ApA, ApG, GpA and GpG. CD study of the effect of 5'-phosphate groups on the conformation of 3'-5' GpG.3'-5' ApA、ApG、GpA和GpG的5'-焦磷酸酯和三磷酸酯衍生物的化学合成。5'-磷酸基团对3'-5' GpG构象影响的圆二色性研究。
Nucleic Acids Res. 1978 Aug;5(8):2945-57. doi: 10.1093/nar/5.8.2945.
4
Synthesis, characterization, and biological properties of 8-azido- and 8-amino-substituted 2',5'-oligoadenylates.8-叠氮基和8-氨基取代的2',5'-寡腺苷酸的合成、表征及生物学性质
J Med Chem. 2003 Nov 6;46(23):4926-32. doi: 10.1021/jm030035k.
5
Characterization of antibody to 2'-5' linked oligoadenylic acid.对2'-5'连接的寡聚腺苷酸抗体的特性鉴定
J Biochem. 1982 Dec;92(6):1723-30. doi: 10.1093/oxfordjournals.jbchem.a134102.
6
Irregularities in the circular dichroism of oligoribonucleotides.寡核糖核苷酸圆二色性的不规则性。
Z Naturforsch C Biosci. 1982 Jul-Aug;37(7-8):727-30. doi: 10.1515/znc-1982-7-827.
7
Synthesis and properties of a modified 2'-5'-adenylate trimer containing 2'-terminal 8-bromoadenosine.
Nucleic Acids Symp Ser. 1985(16):133-6.
8
Synthesis and conformational studies of ribooligonucleotides which contain an alternating C-G sequence and show unusual circular dichroism spectra.含有交替C-G序列并呈现异常圆二色光谱的核糖寡核苷酸的合成与构象研究。
Nucleic Acids Res. 1984 Oct 25;12(20):7793-810. doi: 10.1093/nar/12.20.7793.
9
An approach to prebiotic synthesis of alpha-oligoribonucleotides and description of their properties: selective advantage of beta-RNA over alpha-RNA.α-寡核糖核苷酸的益生元合成方法及其性质描述：β-RNA相对于α-RNA的选择优势。
J Mol Evol. 1997 Sep;45(3):209-15. doi: 10.1007/pl00006222.
10
Influence of terminal 3' phosphates or 2',3'-cyclic phosphates on the conformations of oligoriboadenylates, oligoribocytidylates, and the corresponding monomers.3' 端磷酸或 2',3'-环磷酸对寡聚腺苷酸、寡聚胞苷酸及其相应单体构象的影响。
Biochemistry. 1979 Oct 30;18(22):4936-42. doi: 10.1021/bi00589a023.

引用本文的文献

1
The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation.2-5A系统：通过加速RNA降解来调节病毒和细胞过程。
Pharmacol Ther. 1998 May;78(2):55-113. doi: 10.1016/s0163-7258(97)00167-8.
2
Synthesis and properties of 5'-triphosphoryl 2'-5' oligoadenylates (2-5A), and a general method for synthesis of 3', 5'-bisphosphorylated oligonucleotides.5'-三磷酸化2'-5'寡腺苷酸（2-5A）的合成与性质，以及3',5'-双磷酸化寡核苷酸的通用合成方法。
Nucleic Acids Res. 1981 Apr 24;9(8):2003-20. doi: 10.1093/nar/9.8.2003.
3
Monoclonal antibodies to 5'-triphospho-(2'-5')adenyladenosine oligonucleotides.针对5'-三磷酸-(2'-5')腺苷寡核苷酸的单克隆抗体。
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4742-6. doi: 10.1073/pnas.79.15.4742.
4
Preparation of the individual diastereomers of adenylyl-(2'-5')-P-thioadenylyl-(2'-5')-adenosine and their 5'-phosphorylated derivatives.腺苷酰基-(2'-5')-硫代腺苷酰基-(2'-5')-腺苷及其5'-磷酸化衍生物的各个非对映异构体的制备。
Nucleic Acids Res. 1987 Dec 10;15(23):9933-43. doi: 10.1093/nar/15.23.9933.
5
Conformational studies of (2'-5') polynucleotides: theoretical computations of energy, base morphology, helical structure, and duplex formation.（2'-5'）多核苷酸的构象研究：能量、碱基形态、螺旋结构和双链形成的理论计算
Nucleic Acids Res. 1986 Jul 11;14(13):5461-79. doi: 10.1093/nar/14.13.5461.

本文引用的文献

1
Conformational stability of dinucleotides in solution.溶液中二核苷酸的构象稳定性。
J Mol Biol. 1967 May 14;25(3):481-95. doi: 10.1016/0022-2836(67)90200-8.
2
Adenylate oligomers in single- and double-strand conformation.单链和双链构象的腺苷酸寡聚物。
J Mol Biol. 1966 Feb;15(2):467-88. doi: 10.1016/s0022-2836(66)80122-5.
3
Studies of the conformation and interaction in dinucleoside mono- and diphosphates by proton magnetic resonance.利用质子磁共振研究二核苷单磷酸和二磷酸中的构象与相互作用。
Biochemistry. 1969 Mar;8(3):997-1029. doi: 10.1021/bi00831a033.
4
A new polymer-support method for the synthesis of ribooligonucleotide.一种用于合成核糖寡核苷酸的新型聚合物支持方法。
J Am Chem Soc. 1971 Jun 30;93(13):3272-6. doi: 10.1021/ja00742a029.
5
Oligonucleotide interactions. IV. Conformational differences between deoxy- and ribodinucleoside phosphates.寡核苷酸相互作用。IV. 脱氧和核糖二核苷磷酸之间的构象差异。
Biopolymers. 1970;9(9):1079-103. doi: 10.1002/bip.1970.360090910.
6
Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides.用于检测肽固相合成中游离末端氨基的颜色测试。
Anal Biochem. 1970 Apr;34(2):595-8. doi: 10.1016/0003-2697(70)90146-6.
7
Studies on transfer ribonucleic acids and related compounds. I. Synthesis of ribooligonucleotides using aromatic phosphoramidates as a protecting group.转移核糖核酸及相关化合物的研究。I. 以芳基磷酰胺作为保护基团合成核糖寡核苷酸。
J Am Chem Soc. 1970 Jun 3;92(11):3441-5. doi: 10.1021/ja00714a036.
8
Studies on transfer ribonucleic acids and related compounds. V. Synthesis of ribonucleotides with phosphomonoester end groups on a polymer support.转移核糖核酸及相关化合物的研究。V. 聚合物载体上具有磷酸单酯端基的核糖核苷酸的合成。
J Am Chem Soc. 1972 May 3;94(9):3229-33. doi: 10.1021/ja00764a055.
9
Influence of the phosphodiester linkage (3'-5', 2'-5', and 5'-5') on the conformation of dinucleoside monophosphate.磷酸二酯键（3'-5'、2'-5'和5'-5'）对单磷酸二核苷构象的影响。
Biochemistry. 1970 Sep 1;9(18):3479-98. doi: 10.1021/bi00820a002.
10
Rapid synthesis of oligodeoxyribonucleotides: a new solid-phase method.寡脱氧核糖核苷酸的快速合成：一种新的固相方法。
Nucleic Acids Res. 1977 Apr;4(4):1135-58. doi: 10.1093/nar/4.4.1135.

某些2'-5'-连接的寡聚腺苷酸的快速化学合成及圆二色性特性

Rapid chemical synthesis and circular dichroism properties of some 2'-5'-linked oligoriboadenylates.

作者信息

Markham A F, Porter R A, Gait M J, Sheppard R C, Kerr I M

出版信息

Nucleic Acids Res. 1979 Jun 11;6(7):2569-82. doi: 10.1093/nar/6.7.2569.

DOI:10.1093/nar/6.7.2569
PMID:379823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC327872/
Abstract

Specific synthesis of some oligoadenylates including A2'p5'A2'p5'Ap(2'), the 2'-phosphorylated oligoribonucleotide core of the recently discovered protein synthesis inhibitor pppA2'p5'A2'p5'A is described using a novel solid-phase method. The CD spectra of A2'p5'Ap(2'), A2'p5'A2'p5'Ap(2') and A2'p5'A2'p5'A (derived by treatment of the phosphorylated synthetic trimer with E. coli alkaline phosphatase) are presented. Comparison of the latter spectrum with that of A2'p5'A2'p5'A obtained similarly from a biologically derived sample of pppA2'p5'A2'p5'A provides further evidence that this molecule is in fact the first naturally-occurring 2'-5'-linked oligoribonucleotide.

摘要

本文描述了使用一种新型固相方法特异性合成一些寡聚腺苷酸，包括A2'p5'A2'p5'Ap(2')，即最近发现的蛋白质合成抑制剂pppA2'p5'A2'p5'A的2'-磷酸化寡核糖核苷酸核心。给出了A2'p5'Ap(2')、A2'p5'A2'p5'Ap(2')和A2'p5'A2'p5'A（通过用大肠杆菌碱性磷酸酶处理磷酸化合成三聚体得到）的圆二色光谱。将后一种光谱与从生物来源的pppA2'p5'A2'p5'A样品中类似获得的A2'p5'A2'p5'A光谱进行比较，进一步证明该分子实际上是第一个天然存在的2'-5'-连接的寡核糖核苷酸。