Castleden C M, George C F, Sedgwick E M
Postgrad Med J. 1979 Mar;55(641):159-60. doi: 10.1136/pgmj.55.641.159.
The hangover effects of 768 mg chlormethiazole, an hypnotic with a half-life of approximately 4 hr, were compared with those of placebo in a double-blind cross-over study in 8 young subjects. Ten hours after dosing there were no differences between the preparations in the subjects' psychomotor performance, EEG sleep scores, or visual analogue ratings. Thus, an hypnotic which is rapidly removed from the body may confer considerable advantages. However, all 8 subjects had unpleasant nasal symptoms following chlormethiazole, and it is therefore not an ideal hypnotic for this age group.
在一项针对8名年轻受试者的双盲交叉研究中，将半衰期约为4小时的催眠药氯美噻唑768毫克的宿醉效应与安慰剂的宿醉效应进行了比较。给药10小时后，两种制剂在受试者的精神运动表现、脑电图睡眠评分或视觉模拟评分方面没有差异。因此，一种能迅速从体内清除的催眠药可能具有相当大的优势。然而，所有8名受试者在服用氯美噻唑后都出现了令人不适的鼻部症状，因此它并非这个年龄组的理想催眠药。
