Mead M G, Castleden C M
J R Coll Gen Pract. 1982 Dec;32(245):763-5.
Eleven elderly confused patients were given a single dose of chlormethiazole, temazepam and placebo on separate nights with-in a 10-day period. There was no statistically significant difference between the three treatments the next morning in any of the tests, which included subjective and objective measures of mental ability, orientation and hangover effect. These results mirror those previously found in normal, healthy, elderly patients, and do not therefore support the contention that hypnotics increase confusion in demented patients, or that such patients are more sensitive to their actions. Indeed, plasma drug concentrations were on average twice as high in demented as in normal elderly subjects, thus raising the possibility of decreased sensitivity in the demented group. There was little correlation between plasma concentration and pharmacological effect.
11名老年意识模糊患者在10天内的不同夜晚分别接受了单剂量的氯美噻唑、替马西泮和安慰剂。第二天早上，在包括心理能力、定向力和宿醉效应的主观和客观测量在内的任何测试中，三种治疗方法之间均无统计学上的显著差异。这些结果与之前在正常、健康的老年患者中发现的结果一致，因此不支持催眠药会增加痴呆患者意识模糊的观点，也不支持此类患者对其作用更敏感的观点。事实上，痴呆患者的血浆药物浓度平均是正常老年受试者的两倍，因此增加了痴呆组敏感性降低的可能性。血浆浓度与药理作用之间几乎没有相关性。
