Escolar G, Bastida E, Garrido M, Rodríguez-Gómez J, Castillo R, Ordinas A
Thromb Res. 1986 Dec 15;44(6):837-47. doi: 10.1016/0049-3848(86)90029-0.
Using the Baumgartner perfusion technique, marked sex-related differences in the extent of platelet-subendothelium interaction and in the effect of aspirin (ASA) have been observed. The administration of ASA (150 mg daily for 15 days) to two groups of healthy volunteers, one composed of males and the other of females, proved to block the generation of TXB2 in both cases. The basic pattern of platelet subendothelium interaction, however, was found to be markedly different in both groups studied. In men, aspirin treatment induced a significant reduction in the percentage of platelet thrombi, whereas in women, post ASA values remained at the same level as in control experiments. These results show that in the Baumgartner perfusion system women display a less thrombogenic tendency than men and that 150 mg of ASA administered daily are effective in reducing the extent of platelet-subendothelium interaction in the male group but not in the female group. These findings could explain the absence of benefit observed for women in clinical trials with aspirin.
运用鲍姆加特纳灌注技术，已观察到血小板与内皮下相互作用程度及阿司匹林（ASA）效应存在显著的性别差异。对两组健康志愿者（一组为男性，另一组为女性）给予ASA（每日150毫克，持续15天），结果证明在两种情况下均能阻断TXB2的生成。然而，在所研究的两组中，血小板与内皮下相互作用的基本模式明显不同。在男性中，阿司匹林治疗使血小板血栓百分比显著降低，而在女性中，服用ASA后的数值与对照实验中的水平相同。这些结果表明，在鲍姆加特纳灌注系统中，女性的血栓形成倾向低于男性，并且每日服用150毫克ASA可有效降低男性组中血小板与内皮下相互作用的程度，但对女性组无效。这些发现可以解释在阿司匹林临床试验中未观察到女性受益的原因。
