Majewska Joanna, Berg Andrzej, Jurewicz Joanna, Owczarek Katarzyna, Zajdel Radosław, Kilanowicz Anna, Wasik Andrzej, Rachoń Dominik
Department of Clinical and Experimental Endocrinology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland.
Department of Pharmaceutical Chemistry, Medical University of Gdańsk, Hallera 107, 80-416 Gdańsk, Poland.
Reprod Toxicol. 2024 Jan;123:108511. doi: 10.1016/j.reprotox.2023.108511. Epub 2023 Nov 19.
Bisphenols (BPs) have become a chemical group of special interest due to their ability to interfere with the endocrine system and their ubiquitous presence in the environment. As some of them possess mild estrogenic and anti-androgenic effects, they might be associated with the diagnosis of polycystic ovary syndrome (PCOS). Acting on multiple tissues, BPs exposure may lead to metabolic derangements characteristic for metabolic syndrome (MetS). Therefore, the aim of this study was to determine the potential relationship between exposure to some BPA analogues and features of the MetS in women with PCOS. Serum BPE, BPC, BPG, BPM, BPP, BPZ, BPFL, and BPBP concentrations did not differ significantly between the PCOS (n = 135) and the control subjects (n = 104). However, women whose serum BPM and BPP concentrations were in the highest tertile were more likely to be diagnosed with PCOS (adjusted OR; [95%CI] 0.43; [0.20; 0.89], P < 0.001 and 0.56; [0.27; 0.96], P = 0.049, consequently). Serum concentrations of BPs were not associated with the MetS diagnosis in the PCOS group. There was a negative correlation between the concentrations of serum BPBP and total serum cholesterol (r = - 0.153; P = 0.019), BPE and serum testosterone (r = - 0.160; P = 0.014) as well as BPC and HDL-cholesterol (r = - 0.138; P = 0.036). There was a positive correlation between the concentrations of BPP and serum triglycerides (r = 0.138; P = 0.036). Our results point to the potential association between exposure to BPM, BPP, and the diagnosis of PCOS, along with the impact of BPBP, BPE, BPC, and BPP on the metabolic features of the MetS.
双酚类化合物（BPs）因其干扰内分泌系统的能力以及在环境中的广泛存在，已成为一类备受关注的化学物质。由于其中一些具有轻度雌激素和抗雄激素作用，它们可能与多囊卵巢综合征（PCOS）的诊断有关。BPs作用于多个组织，接触BPs可能导致代谢综合征（MetS）特有的代谢紊乱。因此，本研究的目的是确定接触某些双酚A类似物与PCOS女性代谢综合征特征之间的潜在关系。PCOS组（n = 135）和对照组（n = 104）的血清BPE、BPC、BPG、BPM、BPP、BPZ、BPFL和BPBP浓度无显著差异。然而，血清BPM和BPP浓度处于最高三分位数的女性更有可能被诊断为PCOS（校正OR；[95%CI] 0.43；[0.20；0.89]，P < 0.001和0.56；[0.27；0.96]，P = 0.049）。PCOS组中BPs的血清浓度与代谢综合征的诊断无关。血清BPBP浓度与总血清胆固醇之间存在负相关（r = - 0.153；P = 0.019），BPE与血清睾酮之间存在负相关（r = - 0.160；P = 0.014），BPC与高密度脂蛋白胆固醇之间存在负相关（r = - 0.138；P = 0.036）。BPP浓度与血清甘油三酯之间存在正相关（r = 0.138；P = 0.036）。我们的结果表明，接触BPM、BPP与PCOS诊断之间可能存在关联，以及BPBP、BPE、BPC和BPP对代谢综合征代谢特征的影响。
