Ozga Magdalena, Jurewicz Joanna
Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Chemical Safety).
Int J Occup Med Environ Health. 2025 Apr 23;38(2):98-121. doi: 10.13075/ijomeh.1896.02551. Epub 2025 Apr 7.
Polycystic ovary syndrome (PCOS) is an endocrine disorder manifesting with symptoms such as irregular menstrual cycles, hyperandrogenism, and/or polycystic ovaries. The exact cause of PCOS remains unknown, but it is believed to result from a combination of genetic predisposition, insulin resistance, low-grade inflammation, and excessive androgen production. Various environmental factors, especially endocrine-disrupting chemicals (EDCs), in addition to genetic and hormonal ones, also may influence PCOS. This is one of the first systematic reviews dealing with the exposure to non-persistent endocrine disrupting chemicals and PCOS. The review summarizes the existing knowledge about the association of EDCs with PCOS based on significant findings on the toxicity of various non-persistent environmental EDCs and polycyclic ovarian syndrome risk. A systematic search of the literature was conducted in order to identify proper studies using PubMed, Scopus, Elsevier, and Springer databases. The results of the studies suggest that there is a positive association between bisphenol A (BPA), phthalates, octocrylene, and PCOS. The data concerning triclosan and PCOS were inconclusive. Additionally, no link between the exposures to parabens and PCOS was observed. These results of the presented studies highlight the urgent need for continued research on EDCs and their role in PCOS. Int J Occup Med Environ Health. 2025;38(2):98-121.
多囊卵巢综合征（PCOS）是一种内分泌紊乱疾病，表现为月经周期不规律、高雄激素血症和/或多囊卵巢等症状。PCOS的确切病因尚不清楚，但据信是由遗传易感性、胰岛素抵抗、低度炎症和雄激素分泌过多共同导致的。除了遗传和激素因素外，各种环境因素，尤其是内分泌干扰化学物质（EDCs），也可能影响PCOS。这是首批探讨非持久性内分泌干扰化学物质暴露与PCOS关系的系统评价之一。该评价基于各种非持久性环境EDCs毒性及多囊卵巢综合征风险的重要研究结果，总结了关于EDCs与PCOS关联的现有知识。为了确定合适的研究，我们使用PubMed、Scopus、爱思唯尔和施普林格数据库对文献进行了系统检索。研究结果表明，双酚A（BPA）、邻苯二甲酸盐、二乙氨羟苯甲酰基苯甲酸己酯与PCOS之间存在正相关。关于三氯生和PCOS的数据尚无定论。此外，未观察到对羟基苯甲酸酯暴露与PCOS之间存在关联。这些研究结果凸显了对EDCs及其在PCOS中的作用持续开展研究的迫切需求。《国际职业医学与环境卫生杂志》。2025年；38（2）：98 - 121。
