Meier-Sydow J, Mitrou P S
Prax Klin Pneumol. 1979 Apr;33 Suppl 1:333-40.
The treatment of the Goodpasture syndrome, collagenoses (rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis/scleroderma, matosus, progressive systemic sclerosis/scleroderma, dermatomyositis/polymyositis), necrotizing angiitis (periarteritis nodosa, Wegener's granulomatosis) and idiopathic pulmonary fibrosis is reviewed. Their pathogenesis and morbid anatomy is outlined. The uncommunness of these disorders and their pulmonary manifestations is emphasized. The most frequently employed therapeutic agent are the corticosteroids together with acetylsalicylic acid and indomethacin. The effectiveness of immuno-suppressive and cytostatic drugs (azothioprine, cyclophosphamide, chlorambucil) and of D-penicillamine in the treatment of the different disorders is described. Standard programmes for treating any of these diseases have not yet emerged; the long-term results tend do be unsatisfactory. Co-operation with other specialists (nephrologists, rheumatologists, dermatologists) is often necessary in the treatment of these disorders.
本文综述了肺出血肾炎综合征、胶原病（类风湿性关节炎、系统性红斑狼疮、进行性系统性硬化症/硬皮病、皮肌炎/多肌炎）、坏死性血管炎（结节性多动脉炎、韦格纳肉芽肿病）和特发性肺纤维化的治疗方法。概述了它们的发病机制和病理解剖。强调了这些疾病及其肺部表现的罕见性。最常用的治疗药物是皮质类固醇，以及乙酰水杨酸和吲哚美辛。描述了免疫抑制和细胞毒性药物（硫唑嘌呤、环磷酰胺、苯丁酸氮芥）以及D-青霉胺在治疗不同疾病中的有效性。目前尚未出现针对这些疾病中任何一种的标准治疗方案；长期效果往往不尽人意。在治疗这些疾病时，通常需要与其他专科医生（肾病学家、风湿病学家、皮肤科医生）合作。
