Goyal Abhinav, Layman Andrew J, Bois Melanie C, Maleszewski Joseph J
Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, MN, USA.
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Cardiovasc Pathol. 2024 Jan-Feb;68:107588. doi: 10.1016/j.carpath.2023.107588. Epub 2023 Nov 19.
Lambl excrescences (LEs) were initially described in the mid-1800s during autopsies of human hearts, and their significance and biology have been debated ever since. LEs are typically found on aortic and pulmonary valve (semilunar) cusps. There is debate concerning whether LEs are a significant cause of thromboembolic events, or whether they are harmless growths. However, there have not been many reports discussing LEs, and fewer still have examined the prevalence and characteristics of LEs in healthy human hearts. Those who have examined LE prevalence have reported a very high incidence of LEs (85-90%). Herein, we examine LE prevalence and characteristics (size, location, number) in 403 healthy human hearts across all age groups. We find that the prevalence of LEs in healthy hearts is far lower than previously reported.
兰勃赘生物（LEs）最初是在19世纪中叶对人类心脏进行尸检时被描述的，自那时起其意义和生物学特性就一直存在争议。LEs通常发现于主动脉瓣和肺动脉瓣（半月瓣）瓣叶上。关于LEs是否是血栓栓塞事件的重要原因，或者它们是否是无害的生长物，存在争议。然而，讨论LEs的报告并不多，研究健康人心脏中LEs的患病率和特征的报告更少。那些研究过LEs患病率的人报告LEs的发病率非常高（85 - 90%）。在此，我们研究了403颗各年龄组健康人心脏中LEs的患病率和特征（大小、位置、数量）。我们发现健康心脏中LEs的患病率远低于先前报告的水平。
