Pérez-Díaz Celia, Echeverría Ruth, Pérez-Carrascosa Francisco M, Salcedo-Bellido Inmaculada, Requena Pilar, Barrios-Rodríguez Rocío, Ramos Juan José, Olea Nicolás, Fernández Mariana F, Martín-Olmedo Piedad, Arrebola Juan Pedro
Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, Granada, Spain.
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
iScience. 2025 Jun 16;28(7):112876. doi: 10.1016/j.isci.2025.112876. eCollection 2025 Jul 18.
The aim of this study was to investigate associations between human exposure to persistent organic pollutants and sex hormone levels. The study population ( = 253) was a subsample of GraMo adult cohort, recruited in 2003-2004 in two hospitals from Granada, Spain. Exposure was estimated by analyzing samples of adipose tissue (3 organochlorine pesticides and 3 polychlorinated biphenyls) and serum (4 per- and polyfluoroalkyl substances). Data analyses included robust linear regression and weighted quantile sum regression. In men, PFNA (positively) and PCB-138 (negatively) were associated with testosterone. In premenopausal women, OCPs and PCBs were negatively associated with estradiol and SHBG. PFHxS was inversely related to luteinizing hormone. Additionally, PCB-153 and -180 was positively associated with testosterone. The mixture of PCBs/OCPs was positively associated with testosterone in women and with FSH in men. Our results highlight the potential of chemical mixture exposure to alter sex hormone homeostasis, depending on sex and menopausal status.
本研究的目的是调查人体暴露于持久性有机污染物与性激素水平之间的关联。研究人群（n = 253）是格拉纳达成人队列的一个子样本，于2003年至2004年在西班牙格拉纳达的两家医院招募。通过分析脂肪组织样本（3种有机氯农药和3种多氯联苯）和血清样本（4种全氟和多氟烷基物质）来估计暴露情况。数据分析包括稳健线性回归和加权分位数和回归。在男性中，全氟萘酸（呈正相关）和多氯联苯-138（呈负相关）与睾酮有关。在绝经前女性中，有机氯农药和多氯联苯与雌二醇和性激素结合球蛋白呈负相关。全氟己烷磺酸与促黄体生成素呈负相关。此外，多氯联苯-153和-180与睾酮呈正相关。多氯联苯/有机氯农药混合物在女性中与睾酮呈正相关，在男性中与促卵泡激素呈正相关。我们的结果强调了化学混合物暴露根据性别和绝经状态改变性激素稳态的可能性。
