Department of Laboratory Medicine, University Hospital of North Norway, 9038, Tromsø, Norway; Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway.
Department of Laboratory Medicine, University Hospital of North Norway, 9038, Tromsø, Norway.
Environ Res. 2021 Apr;195:110740. doi: 10.1016/j.envres.2021.110740. Epub 2021 Jan 15.
Prevalence of obesity, hypertension and dyslipidemia has been increasing in children and adolescents worldwide. Exposure to environmental pollutants may contribute to this development. Our aim was to study associations between perfluoroalkyl substances (PFAS) and dyslipidemia, hypertension and obesity in a population-based sample of adolescents.
Serum PFAS concentrations were measured in 940 adolescents, mean age 16.4 (SD 1.3) years, from the cross-sectional Fit Futures study by the UHPLC-MS/MS method. The following endpoints were used: hypertension (systolic blood pressure over 130 mmHg and/or diastolic blood pressure over 80 mmHg); obesity (body mass index over 2 z-score, WHO charts for adolescents); dyslipidemia (total cholesterol ≥ 5.17 mmol/L, and/or LDL-cholesterol ≥ 3.36 mmol/l, and/or apolipoprotein B ≥ 1.10 g/L).
Perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), perfluorodecanoate (PFDA) and perfluoroundecanoate (PFUnDA) serum concentrations were positively associated with apolipoprotein B, total- and LDL cholesterol. The highest vs. lowest quartiles of total PFAS (∑PFAS), PFNA and PFDA concentrations were positively associated with the risk of dyslipidemia: OR 2.24 (95% CI 1.10-4.54), OR 2.30 (95% CI 1.16-4.57) and 2.36 (95% CI 1.08-5.16), respectively. The highest vs. lowest quartiles of ∑PFAS, perfluorohexane sulfonate (PFHxS), PFOS, perfluorooctanoate (PFOA) concentrations were positively associated with the risk of hypertension: OR 1.91 (95% CI 1.12-3.26), OR 2.06 (95% CI 1.16-3.65), 1.86 (95% CI 1.08-3.19) and 2.08 (95% CI 1.17-3.69) respectively. PFHxS and perfluoroheptane sulfonate (PFHpS) concentrations were positively associated with obesity.
This cross-sectional study showed a possible link between several PFAS and dyslipidemia, hypertension and obesity in Norwegian adolescents.
肥胖、高血压和血脂异常在全球儿童和青少年中的发病率不断上升。环境污染物的暴露可能是导致这种发展的原因之一。我们的目的是研究在基于人群的青少年样本中，全氟烷基物质（PFAS）与血脂异常、高血压和肥胖之间的关联。
通过超高效液相色谱-串联质谱法（UHPLC-MS/MS）方法，在来自横断面 Fit Futures 研究的 940 名平均年龄为 16.4（SD 1.3）岁的青少年血清中测量 PFAS 浓度。使用以下终点：高血压（收缩压超过 130mmHg 和/或舒张压超过 80mmHg）；肥胖（体重指数超过 2 个 z 分数，世界卫生组织青少年图表）；血脂异常（总胆固醇≥5.17mmol/L，和/或 LDL-胆固醇≥3.36mmol/L，和/或载脂蛋白 B≥1.10g/L）。
全氟辛烷磺酸（PFOS）、全氟壬酸（PFNA）、全氟癸酸（PFDA）和全氟十一烷酸（PFUnDA）血清浓度与载脂蛋白 B、总胆固醇和 LDL 胆固醇呈正相关。总全氟烷基物质（∑PFAS）、PFNA 和 PFDA 浓度的最高与最低四分位数与血脂异常的风险呈正相关：OR 2.24（95%CI 1.10-4.54）、OR 2.30（95%CI 1.16-4.57）和 2.36（95%CI 1.08-5.16）。∑PFAS、全氟己烷磺酸（PFHxS）、全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）浓度的最高与最低四分位数与高血压的风险呈正相关：OR 1.91（95%CI 1.12-3.26）、OR 2.06（95%CI 1.16-3.65）、OR 1.86（95%CI 1.08-3.19）和 OR 2.08（95%CI 1.17-3.69）。PFHxS 和全氟庚烷磺酸（PFHpS）浓度与肥胖呈正相关。
这项横断面研究表明，在挪威青少年中，几种 PFAS 与血脂异常、高血压和肥胖之间可能存在联系。
