División de Ciencias Agropecuarias e Ingenierías, Centro Universitario de los Altos, Universidad de Guadalajara, Av. Rafael Casillas Aceves 1200, Tepatitlán de Morelos 47600, Jalisco, Mexico.
Laboratorio Integral de Investigación en Alimentos, Tecnológico Nacional de México/Instituto Tecnológico de Tepic, Av. Tecnológico 2595, Tepic 63175, Nayarit, Mexico.
Food Res Int. 2023 Dec;174(Pt 1):113583. doi: 10.1016/j.foodres.2023.113583. Epub 2023 Oct 14.
Nanosuspensions (NSps) are colloidal dispersions of particles that have the potential to solve the delivery problems of active ingredients associated with their low solubility in water or instability due to environmental factors. It is essential to consider their chemical composition and preparation methods because they directly influence drug loading, size, morphology, solubility, and stability; these characteristics of nanosuspensions influence the delivery and bioavailability of active ingredients. NSps provides high loading of drugs, protection against degrading agents, rapid dissolution, high particle stability, and high bioavailability of active ingredients across biological membranes. In addition, they provide lower toxicity compared to other nanocarriers, such as liposomes or polymeric nanoparticles, and can modify the pharmacokinetic profiles, thus improving their safety and efficacy. The present review aims to address all aspects related to the composition of NSps, the different methods for their production, and the main factors affecting their stability. Moreover, recent studies are described as carriers of active ingredients and their biological activities.
纳米混悬剂（NSps）是一种胶体分散体系，其中的粒子具有潜在能力可以解决活性成分因低水溶性或因环境因素不稳定而带来的传递问题。考虑它们的化学组成和制备方法是至关重要的，因为它们直接影响药物的载药量、粒径、形态、溶解度和稳定性；这些纳米混悬剂的特性影响活性成分的传递和生物利用度。NSps 可以实现药物的高载药量、对降解剂的保护、快速溶解、高颗粒稳定性以及活性成分穿过生物膜的高生物利用度。此外，与其他纳米载体（如脂质体或聚合物纳米粒）相比，它们的毒性更低，并且可以改变药代动力学特征，从而提高其安全性和疗效。本综述旨在讨论与 NSps 的组成、不同的生产方法以及影响其稳定性的主要因素有关的所有方面。此外，还描述了最近的研究作为活性成分的载体及其生物活性。
