一种基于Co(TAML)的用于不对称自由基型氧原子转移催化的人工金属酶。
A Co(TAML)-based artificial metalloenzyme for asymmetric radical-type oxygen atom transfer catalysis.
作者信息
Meeus Eva J, Igareta Nico V, Morita Iori, Ward Thomas R, de Bruin Bas, Reek Joost N H
机构信息
Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam (UvA), Science Park 904, Amsterdam 1098XH, The Netherlands.
Department of Chemistry, University of Basel, Mattenstrasse 22, Basel CH-4002, Switzerland.
出版信息
Chem Commun (Camb). 2023 Dec 7;59(98):14567-14570. doi: 10.1039/d3cc04723g.
PMID:37987161
Abstract
We show that the incorporation of a biotinylated Co(TAML) cofactor within streptavidin enables asymmetric radical-type oxygen atom transfer catalysis with improved activity and enantioselectivity.
摘要
我们表明，将生物素化的Co(TAML)辅因子掺入抗生物素蛋白中可实现具有更高活性和对映选择性的不对称自由基型氧原子转移催化。
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