Alrushaid Noor, Khan Firdos Alam, Al-Suhaimi Ebtesam, Elaissari Abdelhamid
Universite Claude Bernard Lyon-1, CNRS, ISA-UMR 5280, 69100 Villeurbanne, France.
Department of Stem Cell Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Diseases. 2023 Oct 24;11(4):148. doi: 10.3390/diseases11040148.
Worldwide, colon cancer is the third most frequent malignancy and the second most common cause of death. Although it can strike anybody at any age, colon cancer mostly affects the elderly. Small, non-cancerous cell clusters inside the colon, commonly known as polyps, are typically where colon cancer growth starts. But over time, if left untreated, these benign polyps may develop into malignant tissues and develop into colon cancer. For the diagnosis of colon cancer, with routine inspection of the colon region for polyps, several techniques, including colonoscopy and cancer scanning, are used. In the case identifying the polyps in the colon area, efforts are being taken to surgically remove the polyps as quickly as possible before they become malignant. If the polyps become malignant, then colon cancer treatment strategies, such as surgery, chemotherapy, targeted therapy, and immunotherapy, are applied to the patients. Despite the recent improvements in diagnosis and prognosis, the treatment of colorectal cancer (CRC) remains a challenging task. The objective of this review was to discuss how CRC is initiated, and its various developmental stages, pathophysiology, and risk factors, and also to explore the current state of colorectal cancer diagnosis and treatment, as well as recent advancements in the field, such as new screening methods and targeted therapies. We examined the limitations of current methods and discussed the ongoing need for research and development in this area. While this topic may be serious and complex, we hope to engage and inform our audience on this important issue.
在全球范围内,结肠癌是第三大常见恶性肿瘤,也是第二大常见死因。尽管任何年龄的人都可能患结肠癌,但结肠癌主要影响老年人。结肠癌的生长通常始于结肠内小的非癌细胞群,即通常所说的息肉。但随着时间的推移,如果不进行治疗,这些良性息肉可能会发展成恶性组织并演变成结肠癌。为了诊断结肠癌,人们采用了多种技术,包括结肠镜检查和癌症扫描,对结肠区域进行息肉的常规检查。在发现结肠区域有息肉的情况下,人们会尽快采取手术切除息肉,以防其恶变。如果息肉恶变,那么就会对患者应用结肠癌治疗策略,如手术、化疗、靶向治疗和免疫治疗。尽管最近在诊断和预后方面有所改善,但结直肠癌(CRC)的治疗仍然是一项具有挑战性的任务。本综述的目的是讨论结直肠癌是如何发生的,以及其各个发展阶段、病理生理学和危险因素,同时探讨结直肠癌诊断和治疗的现状,以及该领域的最新进展,如新的筛查方法和靶向治疗。我们研究了当前方法的局限性,并讨论了该领域持续的研发需求。虽然这个话题可能严肃而复杂,但我们希望能让读者了解并认识到这个重要问题。