FKBP5 相关的 CD8+T 细胞浸润是 luminal B 型乳腺癌的一种新的预后生物标志物。
FKBP5 associated CD8 T cell infiltration is a novel prognostic biomarker in luminal B breast cancer.
机构信息
Department of General Surgery, The People's Hospital of Long you County, Quzhou, Zhejiang Province, China.
Department of General Surgery, Zhejiang Putuo Hospital, Zhoushan, Zhejiang Province, China.
出版信息
J Int Med Res. 2023 Nov;51(11):3000605231211771. doi: 10.1177/03000605231211771.
OBJECTIVE
To investigate the relationship between FKBP prolyl isomerase 5 () gene expression and CD8 T cells in tumour progression and immunology of the luminal B subtype of breast cancer (LBBC) using bioinformatics analyses.
METHODS
The Gene Expression Profiling Interactive Analysis 2, Human Protein Atlas and breast cancer gene-expression miner v4.5 databases were used for data mining and analysing , its co-expressed genes and CD8 T cell-related markers. The Tumor IMmune Estimation Resource 2.0 database was used for analysing the correlation and prognosis of and CD8 T cell infiltration level in LBBC.
RESULTS
Upregulated expression was correlated with improved survival in LBBC. Upregulated -related CD8 T cell markers were also demonstrated to be significantly correlated with better survival in LBBC and might play a role in the biological activity of .
CONCLUSION
These findings suggest that and its associated CD8 T cell infiltration are potential benign prognostic indicators for LBBC.
目的
利用生物信息学分析研究 FKBP 脯氨酰异构酶 5()基因表达与腔 B 型乳腺癌（LBBC）肿瘤进展和免疫中 CD8 T 细胞的关系。
方法
使用基因表达谱交互分析 2、人类蛋白质图谱和乳腺癌基因表达挖掘者 v4.5 数据库进行数据挖掘和分析，分析其共表达基因和 CD8 T 细胞相关标志物。使用肿瘤免疫估计资源 2.0 数据库分析 LBBC 中与 CD8 T 细胞浸润水平相关的和表达的相关性和预后。
结果
上调的表达与 LBBC 中改善的生存相关。上调的相关 CD8 T 细胞标志物也与 LBBC 中更好的生存显著相关，可能在的生物学活性中发挥作用。
结论
这些发现表明和其相关的 CD8 T 细胞浸润可能是 LBBC 的潜在良性预后指标。
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