Department of Dermatology and Venereology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
Department of Dermatology and Allergy, Herlev and Gentofte Hospital, Hellerup, Denmark.
Contact Dermatitis. 2024 Apr;90(4):350-364. doi: 10.1111/cod.14456. Epub 2023 Nov 22.
The international classification of diseases, 10th revision (ICD-10) includes several unvalidated diagnostic codes for hand eczema (HE). Knowledge is sparse on HE patient characteristics.
To validate selected HE ICD-10 codes in the Danish National Patient Registry (DNPR) and describe disease characteristics, lifestyle factors and medication use in adult HE patients.
Nineteen HE ICD-10 codes were selected and validated based on patient charts. Five cohorts were constructed based on the diagnostic code, DL30.8H (HE unspecified), in the DNPR: (i) patients with DL30.8H code (n = 8386), (ii) patients with DL30.8H code, but without atopic dermatitis (AD) (n = 7406), (iii) sex- and age-matched general population (n = 8386) without HE. Two additional cohorts nested in the DNPR included participants from the Danish Skin Cohort, (iv) patients with DL30.8H code but without AD (n = 1340) and (v) general population cohort (n = 9876).
ICD-10 codes revealed positive predictive values ≥90% except irritant contact dermatitis (unspecified) (79.7%) and hyperkeratotic hand and foot eczema (84.1%). HE patients were most often women, middle-aged or older, of Danish ethnicity, had an atopic medical history and were smokers. Topical corticosteroid prescriptions were almost doubled in HE cohorts compared to general populations.
We validated several HE ICD-10 codes and identified important HE patient characteristics.
国际疾病分类第 10 版（ICD-10）包括几个未经验证的手部湿疹（HE）诊断代码。关于 HE 患者特征的知识很少。
验证丹麦国家患者登记处（DNPR）中选定的 HE ICD-10 代码，并描述成年 HE 患者的疾病特征、生活方式因素和药物使用情况。
根据患者图表，选择并验证了 19 个 HE ICD-10 代码。根据 DNPR 中的诊断代码 DL30.8H（未特指的 HE）构建了五个队列：（i）DL30.8H 代码患者（n=8386），（ii）DL30.8H 代码患者，但无特应性皮炎（AD）（n=7406），（iii）性别和年龄匹配的无 HE 的一般人群（n=8386）。DNPR 中嵌套的另外两个队列包括丹麦皮肤队列的参与者，（iv）无 AD 的 DL30.8H 代码患者（n=1340）和（v）一般人群队列（n=9876）。
除刺激性接触性皮炎（未特指）（79.7%）和角化过度性手足湿疹（84.1%）外，ICD-10 代码的阳性预测值均≥90%。HE 患者多为女性，年龄在中年或以上，具有丹麦种族背景，有特应性病史，且为吸烟者。与一般人群相比，HE 队列中的局部皮质类固醇处方几乎增加了一倍。
我们验证了几个 HE ICD-10 代码，并确定了重要的 HE 患者特征。
