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丹麦特应性皮炎患儿和成人的人口统计学、医疗保健利用和药物使用情况:一项基于人群的横断面研究。

Demographics, healthcare utilization and drug use in children and adults with atopic dermatitis in Denmark: a population-based cross-sectional study.

机构信息

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, Hellerup, Denmark.

Copenhagen Research Group for Inflammatory Skin (CORGIS), Hellerup, Denmark.

出版信息

J Eur Acad Dermatol Venereol. 2019 Jun;33(6):1133-1142. doi: 10.1111/jdv.15424. Epub 2019 Mar 5.

DOI:10.1111/jdv.15424
PMID:30633387
Abstract

BACKGROUND

Atopic dermatitis (AD) is a common inflammatory skin condition. While previous publications have examined healthcare expenses, large data regarding patient demographics, healthcare use and drug prescriptions are limited.

OBJECTIVE

To examine demographics, healthcare use and drug prescriptions in children and adults with hospital-diagnosed AD.

METHODS

Danish nationwide registries were cross-linked to access demographic, healthcare and drug prescription data on children and adults with hospital-diagnosed AD (ICD-10 code L20). The diagnostic code for AD used in this study was validated by reviewing medical charts.

RESULTS

We identified 9704 children (time period 1997-2012) and 5558 adults (time period 1997-2007) with hospital-diagnosed AD. The diagnostic code L20 had a positive predictive value of 95%. Among children with AD, a larger proportion came from less resourceful families and had immigrant parents from non-European countries. In adults, we observed an opposite tendency. Topical and systemic antibiotics were used relatively frequent in both children and adults with AD. The use of prednisolone and other systemic anti-inflammatory therapy was substantially higher in adults with AD than in children.

LIMITATIONS

We were unable to identify and describe patients treated by general and private practitioners.

CONCLUSION

There exist significant differences in social predictors for AD and the use of AD medication between children and adults with hospital-diagnosed AD in Denmark. The diagnostic code for AD appears to be valid in Danish registries.

摘要

背景

特应性皮炎(AD)是一种常见的炎症性皮肤病。虽然之前的研究已经探讨了医疗保健费用,但关于患者人口统计学、医疗保健使用和药物处方的大型数据有限。

目的

研究丹麦有医院诊断的 AD 儿童和成人的人口统计学、医疗保健使用和药物处方情况。

方法

通过交叉链接丹麦全国性登记处,获取有医院诊断的 AD(ICD-10 编码 L20)儿童和成人的人口统计学、医疗保健和药物处方数据。本研究中使用的 AD 诊断代码通过审查病历进行了验证。

结果

我们确定了 9704 名儿童(1997-2012 年期间)和 5558 名成人(1997-2007 年期间)患有医院诊断的 AD。AD 的诊断代码 L20 的阳性预测值为 95%。在患有 AD 的儿童中,更多的儿童来自资源较少的家庭,父母是来自非欧洲国家的移民。在成人中,我们观察到了相反的趋势。局部和全身抗生素在患有 AD 的儿童和成人中都相对频繁使用。与儿童相比,患有 AD 的成人中使用泼尼松龙和其他全身抗炎治疗的比例明显更高。

局限性

我们无法识别和描述在丹麦由普通医生和私人医生治疗的患者。

结论

丹麦有医院诊断的 AD 儿童和成人在 AD 的社会预测因素和 AD 药物使用方面存在显著差异。丹麦登记处的 AD 诊断代码似乎是有效的。

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