Wenzelides K, Hufnagl P, Voss K, Guski H, Simon H
Zentralbl Allg Pathol. 1986;132(4):301-6.
Studies were undertaken on biopsies from urinary bladder papillomas and urothelial carcinomas of different grades (G1-G3) along with normal urinary bladder mucosa from a total of 145 patients. They were performed by use of automated microscopic image analysis (system Robotron A 6471; software AMBA/R) and resulted in making objective the tumor grading and lead to the detection of both papillomas and G1-carcinomas with high proliferating activity. In addition, we were able to separate the G2-carcinomas into two groups which probably show different biological behaviour. They cannot be discriminated by conventional morphological methods but their existence is consistent with clinical observations.
对145例患者的膀胱乳头状瘤、不同分级（G1 - G3）的尿路上皮癌活检组织以及正常膀胱黏膜进行了研究。研究采用自动显微镜图像分析（Robotron A 6471系统；AMBA/R软件）进行，实现了肿瘤分级的客观化，并检测出具有高增殖活性的乳头状瘤和G1级癌。此外，我们能够将G2级癌分为两组，这两组可能表现出不同的生物学行为。它们无法通过传统形态学方法区分，但它们的存在与临床观察结果一致。
