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[现代流感疫苗免疫化学纯度分析]

[Analysis of the immunochemical purity of modern influenza vaccines].

作者信息

Zhebrun A B, Polianskaia N Iu, Bichurina M A, Rozaeva N R, Fridman E A

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1986 Oct(10):56-9.

PMID:3799103
Abstract

Corpuscular influenza vaccines have been found to contain chick embryo antigens differing from ovalbumin in their antigenic, immunogenic, and allergenic properties. The study has revealed that host antigens are present in vaccines in the form of free contaminants and as substances incorporated into viruses. The vaccine prepared by the method of sorption-elution on red blood cells with subsequent gel chromatography is characterized by the highest antigenic purity.

摘要

已发现微粒流感疫苗含有在抗原性、免疫原性和变应原性方面不同于卵清蛋白的鸡胚抗原。该研究表明,宿主抗原以游离污染物的形式以及作为掺入病毒的物质存在于疫苗中。通过在红细胞上进行吸附-洗脱并随后进行凝胶色谱法制备的疫苗具有最高的抗原纯度。

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