Center for Health and Diseases Scieces Research School of Dentistry, Benito Juárez Autonomous University of Oaxaca Universidad avenue, "Ex-Hacienda de Cinco Señores" Zip code: 68120, Oaxaca, Mexico
Med Oral Patol Oral Cir Bucal. 2024 Jan 1;29(1):e9-e17. doi: 10.4317/medoral.25987.
Chitosan is a cheap, accessible, nontoxic, biocompatible, and biodegradable compound. Also, this polysaccharide possesses antibacterial and anti-inflammatory properties. Consequently, a wide range of chitosan applications in the dentistry field has been explored. This work aimed to conduct a systematic review to address the clinical efficacy of chitosan for the treatment of oral mucositis.
The design of the included studies were observational studies, randomized clinical trials (RCT), and non-randomized clinical trials (non-RCT), whereas, a series of cases, in vivo, and in vitro studies were excluded. The search was performed in PubMed, Web of Science, Scopus, Dentistry and Oral Sciences Source, and ClinicalTrials. Gray literature was searched at Google Scholar. Relevant data from all included studies were recorded. The risk of bias (using RoB 2) and the quality (using Grading of Recommendations Assessment, Development, and Evaluation, GRADE) assessments were carried out.
From the 8413 records screened, 5 clinical trials fully met the eligibility criteria, which comprised a total of 192 participants suffering oral lesions and pain related to oral mucositis. 100% of the included studies exhibited a high risk of bias. The quality of the studies was between low and very low.
The results of the included studies suggest that chitosan can diminish pain and improve the healing of ulcers in oral mucositis. However, there is no conclusive evidence of chitosan as a superior treatment for oral mucositis compared with other current therapies.
壳聚糖是一种廉价、易得、无毒、生物相容和可生物降解的化合物。此外，这种多糖具有抗菌和抗炎特性。因此，壳聚糖在牙科领域的广泛应用已经得到了探索。本研究旨在进行系统评价，以解决壳聚糖治疗口腔黏膜炎的临床疗效问题。
纳入研究的设计为观察性研究、随机临床试验（RCT）和非随机临床试验（非 RCT），而排除了一系列病例、体内和体外研究。检索了 PubMed、Web of Science、Scopus、Dentistry and Oral Sciences Source 和 ClinicalTrials。在 Google Scholar 上搜索灰色文献。记录所有纳入研究的相关数据。使用 RoB 2 进行偏倚风险评估，使用 GRADE 进行质量评估。
从 8413 条筛选记录中，有 5 项临床试验完全符合纳入标准，共纳入 192 名患有口腔病变和与口腔黏膜炎相关疼痛的患者。纳入研究的 100%均存在高偏倚风险。研究质量介于低和极低之间。
纳入研究的结果表明，壳聚糖可以减轻疼痛并促进口腔黏膜炎溃疡的愈合。然而，与其他现有疗法相比，壳聚糖作为口腔黏膜炎的治疗方法是否具有优势，尚无确凿证据。
