Division of Cardiology, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts, USA.
Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland, USA.
J Am Coll Cardiol. 2023 Nov 28;82(22):2128-2151. doi: 10.1016/j.jacc.2023.09.819.
Derangements in the innate and adaptive immune responses observed in systemic inflammatory syndromes contributes to unique elevated atherosclerotic risk and incident cardiovascular disease. Novel multimodality imaging techniques may improve diagnostic precision for the screening and monitoring of disease activity. The integrated application of these technologies lead to earlier diagnosis and noninvasive monitoring of cardiac involvement in systemic inflammatory diseases that will aid in preclinical studies, enhance patient selection, and provide surrogate endpoints in clinical trials, thereby improving clinical outcomes. We review the common cardiovascular manifestations of immune-mediated systemic inflammatory diseases and address the clinical and investigational role of advanced multimodality cardiac imaging.
全身性炎症综合征中观察到的先天和适应性免疫反应失调导致独特的动脉粥样硬化风险升高和心血管疾病事件。新型多模态成像技术可能提高疾病活动筛查和监测的诊断精度。这些技术的综合应用可实现全身性炎症性疾病心脏受累的早期诊断和非侵入性监测，有助于临床前研究，增强患者选择，并在临床试验中提供替代终点，从而改善临床结局。我们回顾了免疫介导的全身性炎症性疾病的常见心血管表现，并探讨了先进的多模态心脏成像的临床和研究作用。
