银屑病性疾病中的心血管疾病风险：机制及对临床实践的意义
Cardiovascular disease risk in psoriatic disease: mechanisms and implications for clinical practice.
作者信息
Medamana John L, Gelfand Joel M, Weber Brittany N, Garshick Michael S
机构信息
Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York.
Department of Dermatology and Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Sciences in Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia.
出版信息
Curr Opin Rheumatol. 2025 Jul 1;37(4):261-268. doi: 10.1097/BOR.0000000000001092. Epub 2025 May 13.
PURPOSE OF REVIEW
Psoriasis is an immune-mediated pro-inflammatory skin condition that is associated with an increase in risk factors for cardiovascular disease, risk of ischemic heart disease, and cardiovascular death. Despite this, traditional modifiable atherosclerotic cardiovascular disease (ASCVD) risk factors are underdiagnosed and undertreated in patients with psoriasis.
RECENT FINDINGS
At a cellular level, psoriasis and atherosclerosis are driven by a host of shared inflammatory pathways, such as pro-inflammatory cytokines (TNF, IL-6), immune cells, and platelets which act synergistically to drive endothelial damage and atherosclerosis progression.
SUMMARY
Optimal prevention of cardiovascular disease in psoriasis centers around modifying known risk factors for the development of ASCVD and emerging data highlight the promise of treating inflammation to further decrease the risk of ASCVD.
综述目的
银屑病是一种免疫介导的炎症性皮肤病，与心血管疾病的危险因素增加、缺血性心脏病风险及心血管死亡风险相关。尽管如此，传统的可改变的动脉粥样硬化性心血管疾病（ASCVD）危险因素在银屑病患者中仍未得到充分诊断和治疗。
最新发现
在细胞水平上，银屑病和动脉粥样硬化由一系列共同的炎症途径驱动，如促炎细胞因子（TNF、IL-6）、免疫细胞和血小板，它们协同作用以驱动内皮损伤和动脉粥样硬化进展。
总结
银屑病中心血管疾病的最佳预防围绕着改变已知的ASCVD发生危险因素，新出现的数据凸显了治疗炎症以进一步降低ASCVD风险的前景。
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