Department of Gastroenterology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.
BMJ Ment Health. 2023 Nov 22;26(1):e300864. doi: 10.1136/bmjment-2023-300864.
Psychiatric disorders have serious harm to individuals' lives with high disease burden. Observational studies reported inconsistent associations between periodontitis and some psychiatric disorders, and the causal correlations between them remain unknown.
This study aims to explore the causal associations between periodontitis and psychiatric disorders.
A series of two-sample Mendelian randomisation (MR) analyses were employed using genome-wide association study summary statistics for periodontitis in adults from Gene-Lifestyle Interactions in Dental Endpoints Consortium and 10 psychiatric disorders from Psychiatric Genomics Consortium. Causal effects were primarily estimated using the inverse-variance weighted (IVW) method. Various sensitivity analyses were also conducted to assess the robustness of our results.
The MR analysis suggested that genetically determined periodontitis was not causally associated with 10 psychiatric disorders (IVW, all p>0.089). Furthermore, the reverse MR analysis revealed that 10 psychiatric disorders had no causal effect on periodontitis (IVW, all p>0.068). We discovered that all the results were consistent in the four MR analytical methods, including the IVW, MR-Egger, weighted median and weighted mode. Besides, we did not identify any heterogeneity or horizontal pleiotropy in the sensitivity analysis.
These results do not support bidirectional causal associations between genetically predicted periodontitis and 10 common psychiatric disorders. Potential confounders might contribute to the previously observed associations.
Our findings might alleviate the concerns of patients with periodontitis or psychiatric disorders. However, further research was warranted to delve into the intricate relationship between dental health and mental illnesses.
精神疾病对个人生活造成严重危害，疾病负担沉重。观察性研究报告称，牙周炎与一些精神疾病之间存在不一致的关联，它们之间的因果关系尚不清楚。
本研究旨在探讨牙周炎与精神疾病之间的因果关系。
使用成人牙周炎基因-生活方式相互作用研究联盟的全基因组关联研究汇总统计数据和精神病学基因组学联盟的 10 种精神疾病，进行了一系列两样本孟德尔随机化（MR）分析。主要使用逆方差加权（IVW）法估计因果效应。还进行了各种敏感性分析，以评估我们结果的稳健性。
MR 分析表明，遗传决定的牙周炎与 10 种精神疾病之间没有因果关系（IVW，所有 p>0.089）。此外，反向 MR 分析表明，10 种精神疾病对牙周炎没有因果影响（IVW，所有 p>0.068）。我们发现，在 IVW、MR-Egger、加权中位数和加权模式这四种 MR 分析方法中，所有结果都是一致的。此外，在敏感性分析中，我们没有发现任何异质性或水平多效性。
这些结果不支持遗传预测的牙周炎与 10 种常见精神疾病之间存在双向因果关系。潜在的混杂因素可能导致之前观察到的关联。
我们的发现可能减轻牙周炎或精神疾病患者的担忧。然而，需要进一步的研究来深入探讨口腔健康与精神疾病之间的复杂关系。
