Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany.
Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany.
Front Immunol. 2022 Jul 22;13:918404. doi: 10.3389/fimmu.2022.918404. eCollection 2022.
Observational and research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation.
The study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,563 to 797,563 individuals of European ancestry. We performed linkage disequilibrium score regression (LDSC) to estimate global correlation and used Heritability Estimation from Summary Statistics (ρ-HESS) to further examine local genetic correlation. Latent Heritable Confounder Mendelian randomization (LHC-MR), Causal Analysis using Summary Effect estimates (CAUSE), and conventional MR approaches assessed bidirectional causation.
LDSC observed only weak genetic correlation (r = 0.06, P-Value = 0.619) between depression and periodontitis. Analysis of local genetic correlation using ρ-HESS did not reveal loci of significant local genetic covariance. LHC-MR, CAUSE and conventional MR models provided no support for bidirectional causation between depression and periodontitis, with odds ratios ranging from 1.00 to 1.06 in either direction.
Results do not support shared heritability or a causal connection between depression and periodontitis.
观察性研究和研究表明抑郁和牙周炎之间存在双向关系。我们估计了遗传相关性，并检查了因果关系的方向。
该研究使用了来自已发表的全基因组关联研究的汇总统计数据，样本量范围从 45563 到 797563 名欧洲血统个体。我们进行了连锁不平衡得分回归（LDSC）以估计全局相关性，并使用来自汇总统计数据的遗传力估计（ρ-HESS）进一步检查局部遗传相关性。潜在可遗传混杂孟德尔随机化（LHC-MR）、使用汇总效应估计的因果分析（CAUSE）和常规 MR 方法评估了双向因果关系。
LDSC 仅观察到抑郁和牙周炎之间微弱的遗传相关性（r = 0.06，P 值 = 0.619）。使用 ρ-HESS 进行局部遗传相关性分析并未发现显著的局部遗传协方差的位置。LHC-MR、CAUSE 和常规 MR 模型均未支持抑郁和牙周炎之间的双向因果关系，在任何方向的比值比均在 1.00 到 1.06 之间。
结果不支持抑郁和牙周炎之间存在共同遗传性或因果关系。
