Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
Doctorate School, Semmelweis University, Budapest, Hungary.
Sci Rep. 2023 Nov 22;13(1):20446. doi: 10.1038/s41598-023-47307-1.
Due to the similarity between the pathomechanism of SARS-CoV-2 infections and hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE), a possibility emerged that C1-INH-HAE may worsen the course of the infection, or that the infection may influence the severity of angioedema (HAE) attacks in C1-INH-HAE patients. Our study aimed to evaluate the effects of the COVID-19 pandemic on the quality of life (QoL) of Hungarian C1-INH-HAE patients, and to survey the acute course of the infection, post COVID symptoms (PCS), vaccination coverage and the side effects of vaccines in this patient population. 93 patients completed our questionnaire between 1st July 2021 and 31st October 2021. In this same period and between March 2019 and March 2020, 63 patients completed the angioedema quality of life questionnaire (AE-QoL). Out of those patients infected with SARS-CoV-2 in the examined period (18/93 patients; 19%), 5% required hospitalization, 28% experienced HAE attacks in the acute phase of the infection, and 44% experienced PCS. A total number of 142 doses of vaccines were administered to the patients. Serious vaccine reactions did not occur in any case, 4 (5%) out of the 73 vaccinated patients experienced HAE attacks. No significant difference (p = 0.59) was found in the median of the AE-QoL total score, or in the number of HAE attacks prior and during the pandemic. Based on our study, HAE patients did not experience more serious SARS-CoV-2 infection, and it did not aggravate the course of HAE either. Changes in the QoL were not significant, and vaccines were safe in HAE patients.
由于 SARS-CoV-2 感染与 C1 抑制剂缺乏症（C1-INH-HAE）所致遗传性血管性水肿的发病机制相似，因此出现了一种可能性，即 C1-INH-HAE 可能会使感染的病程恶化，或者感染可能会影响 C1-INH-HAE 患者血管性水肿（HAE）发作的严重程度。我们的研究旨在评估 COVID-19 大流行对匈牙利 C1-INH-HAE 患者生活质量（QoL）的影响，并调查该患者人群中感染的急性过程、新冠后症状（PCS）、疫苗接种覆盖率和疫苗的副作用。93 名患者于 2021 年 7 月 1 日至 2021 年 10 月 31 日期间完成了我们的问卷。在同一时期以及 2019 年 3 月至 2020 年 3 月期间，有 63 名患者完成了血管性水肿生活质量问卷（AE-QoL）。在研究期间感染 SARS-CoV-2 的患者（93 例患者中的 18 例；19%）中，有 5%需要住院治疗，28%在感染急性期出现 HAE 发作，44%出现 PCS。共给患者接种了 142 剂疫苗。没有出现严重的疫苗反应，在接种疫苗的 73 名患者中，有 4 名（5%）出现 HAE 发作。AE-QoL 总分的中位数或大流行前后 HAE 发作的数量没有显著差异（p=0.59）。根据我们的研究，HAE 患者没有经历更严重的 SARS-CoV-2 感染，也没有加重 HAE 的病程。生活质量的变化不显著，疫苗对 HAE 患者是安全的。
