Rios Rodriguez Misleydi, Singh Jake, Nwakudu Kindness, Feely Shannon, Khaliq Anila, Manna David
Family Medicine, Touro College of Osteopathic Medicine, Middletown, USA.
Family Medicine, Garnet Health Medical Center, Middletown, USA.
Cureus. 2024 Oct 6;16(10):e70951. doi: 10.7759/cureus.70951. eCollection 2024 Oct.
Ongoing research continues to uncover the long-term effects of post-COVID-19 illnesses. Patients with hereditary angioedema (HAE) are believed to have an elevated risk of contracting COVID-19 caused by SARS-CoV-2, potentially leading to increased frequency or more severe symptoms. This speculation is based on the understanding that COVID-19 enters cells through the angiotensin-converting enzyme 2 (ACE2) receptor. This report presents the case of a 37-year-old man with no significant medical history who presented to the clinic with what was initially thought to be an allergic reaction. He had experienced swelling in his lips, both upper extremities, and widespread urticaria, along with mild associated abdominal pain. While there is currently no conclusive evidence linking COVID-19 to the onset of HAE, a significant number of cases suggest a potential connection between post-COVID-19 angioedema and long-term angioedema. Subsequently, the patient experienced a second episode of angioedema flare-up aggravated by an upper respiratory infection.
正在进行的研究不断揭示新冠后疾病的长期影响。遗传性血管性水肿（HAE）患者被认为感染由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的新冠肺炎的风险较高，这可能导致症状发作频率增加或症状更严重。这种推测基于这样的认识，即新冠肺炎通过血管紧张素转换酶2（ACE2）受体进入细胞。本报告介绍了一名37岁男性的病例，他没有重大病史，最初因疑似过敏反应前往诊所就诊。他出现了嘴唇、双上肢肿胀以及广泛的荨麻疹，同时伴有轻度腹痛。虽然目前尚无确凿证据表明新冠肺炎与HAE的发病有关，但大量病例表明新冠后血管性水肿与长期血管性水肿之间可能存在联系。随后，该患者因上呼吸道感染加重，经历了第二次血管性水肿发作。
