Department of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230032, China.
Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, 238000, China.
BMC Psychiatry. 2023 Nov 22;23(1):867. doi: 10.1186/s12888-023-05375-7.
Increasing evidence shows that bone turnover markers (BTMs) and vitamin D can affect human cognitive function. However, there are few studies that have investigated the association between BTMs and cognitive function in chronic schizophrenia patients. The aim of this study was to investigate the relationship between BTMs and cognitive function in chronic schizophrenia patients with or without vitamin D insufficiency (VDI).
In all, 118 chronic schizophrenia patients were enrolled in this cross-sectional study. Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was applied to evaluate the cognitive function of the subjects. Blood analysis included bone turnover markers, vitamin D levels, and glycolipid levels.
Relative to 72 vitamin D-sufficient (VDS) patients, 46 VDI patients had higher bone resorption markers levels and lower bone formation markers levels. Regression analysis showed that, in the total sample, CTX and language function exhibited independent positive correlation (p = 0.027, R change = 0.042), and in the VDS group, procollagen type I N-terminal propeptide (PINP) was independently negatively correlated with language function (p = 0.031, R change = 0.065), while the positive correlation between osteopontin (OPN) and delayed memory remained in the VDI group (p = 0.036, R change = 0.083).
Our study showed an association between the levels of BTMs and cognitive function among chronic schizophrenia patients. This correlation may have different mechanisms of action at different vitamin D levels.
越来越多的证据表明，骨转换标志物（BTMs）和维生素 D 会影响人类的认知功能。然而，很少有研究调查 BTMs 与慢性精神分裂症患者认知功能之间的关系。本研究旨在探讨维生素 D 不足（VDI）和不不足的慢性精神分裂症患者的 BTMs 与认知功能之间的关系。
本研究共纳入 118 例慢性精神分裂症患者。采用重复神经心理状态评估量表（RBANS）评估受试者的认知功能。血液分析包括骨转换标志物、维生素 D 水平和糖脂水平。
与 72 例维生素 D 充足（VDS）患者相比，46 例 VDI 患者的骨吸收标志物水平较高，骨形成标志物水平较低。回归分析显示，在总样本中，CTX 与语言功能呈独立正相关（p=0.027，R 变化=0.042），在 VDS 组中，I 型前胶原 N 端前肽（PINP）与语言功能呈独立负相关（p=0.031，R 变化=0.065），而骨桥蛋白（OPN）与延迟记忆之间的正相关在 VDI 组中仍然存在（p=0.036，R 变化=0.083）。
我们的研究表明，慢性精神分裂症患者的 BTMs 水平与认知功能之间存在关联。这种相关性在不同的维生素 D 水平下可能有不同的作用机制。
