Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Outpatient, Xuzhou Central Hospital, Xuzhou, China.
Eur J Clin Invest. 2023 Oct;53(10):e14038. doi: 10.1111/eci.14038. Epub 2023 Jun 14.
The effects of vitamin D administration on bone turnover markers (BTMs) in adults are controversial. Thus, we carried out a meta-analysis of available randomised controlled trials (RCTs) to examine the impact of vitamin D supplementation on BTMs.
To identify relevant RCTs, we searched the PubMed/MEDLINE, Web of Science, Scopus, Cochrane Library and Embase databases for manuscripts published up to July 2022. The present study was conducted in agreement with the PRISMA guidelines. Weighed mean difference (WMD) and 95% confidence intervals (CI) were used to calculate the magnitude of the effect of the intervention.
A total of 42 RCTs were included in the meta-analysis. The age of the participants enrolled in the RCTs ranged from 19.4 to 84 years. The pooled results depicted a decrease in deoxypyridinoline (DPD) concentrations (WMD: -1.58 nmol/mmol, 95% CI: -2.55, -.61, p = .001) following vitamin D supplementation. In addition, subgroup analyses demonstrated that vitamin D administration notably reduced procollagen type I N-terminal propeptide (PINP) levels in individuals aged >50 years and led to a pronounced decrease in alkaline phosphatase (ALP) values when the intervention lasted >12 weeks. No significant effect was observed on other BTMs, for example, collagen type 1 cross-linked C-telopeptide (CTX) and osteocalcin (OC) levels.
Vitamin D administration decreases DPD, PINP and ALP levels, indicating a reduced bone turnover following the intervention. Other BTMs, for example, CTX or OC values, were not affected by vitamin D prescription. Vitamin D supplementation may exert a positive effect on some important BTMs.
维生素 D 对成年人骨转换标志物（BTM）的影响存在争议。因此，我们进行了一项荟萃分析，以评估维生素 D 补充对 BTM 的影响。
为了确定相关的随机对照试验（RCT），我们检索了 PubMed/MEDLINE、Web of Science、Scopus、Cochrane 图书馆和 Embase 数据库，以获取截至 2022 年 7 月发表的文献。本研究按照 PRISMA 指南进行。我们使用加权均数差（WMD）和 95%置信区间（CI）来计算干预的效果大小。
共有 42 项 RCT 纳入荟萃分析。RCT 参与者的年龄范围为 19.4 至 84 岁。汇总结果显示，维生素 D 补充后脱氧吡啶啉（DPD）浓度降低（WMD：-1.58 nmol/mmol，95%CI：-2.55，-0.61，p=0.001）。此外，亚组分析表明，维生素 D 治疗可显著降低 50 岁以上人群的 I 型前胶原 N 端前肽（PINP）水平，并在干预持续时间>12 周时显著降低碱性磷酸酶（ALP）值。其他 BTM 如 I 型胶原交联 C 端肽（CTX）和骨钙素（OC）水平没有显著影响。
维生素 D 治疗可降低 DPD、PINP 和 ALP 水平，表明干预后骨转换减少。其他 BTM 如 CTX 或 OC 值不受维生素 D 处方的影响。维生素 D 补充可能对某些重要的 BTM 产生积极影响。
Zotero 插件