The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
The people's Hospital of Qiandongnan Autonomous Prefecture, Kaili, Guizhou, China.
Front Endocrinol (Lausanne). 2023 Aug 29;14:1197730. doi: 10.3389/fendo.2023.1197730. eCollection 2023.
No existing comprehensive Mendelian randomization studies have focused on how obesity affects respiratory diseases.
BMI and waist circumference, mainly from the UK Biobank, and 35 respiratory diseases from the FinnGen Biobank were subjected to Mendelian randomization analyses. In this study, the inverse variance weighting method was used as the predominant analysis method and was complemented by MR-Egger and weighted median methods. Horizontal pleiotropy and potential outliers were detected by employing the MR-PRESSO method.
This study indicated that obesity rises the possibility of acute upper respiratory infections (BMI: OR=1.131, p<0.0001; WC: OR=1.097, p=0.00406), acute sinusitis (BMI: OR=1.161, p=0.000262; WC: OR=1.209, p=0.000263), acute pharyngitis (WC: OR=1.238, p=0.0258), acute laryngitis and tracheitis (BMI: OR=1.202, p=0.0288; WC: OR=1.381, p=0.00192), all influenza (BMI: OR=1.243, p=0.000235; WC: OR=1.206, p=0.0119), viral pneumonia (WC: OR=1.446, p=0.000870), all pneumoniae (BMI: OR=1.174, p <0.0001; WC: OR=1.272, p <0.0001), bacterial pneumoniae (BMI: OR=1.183, p=0.000290; WC: OR=1.274, p<0.0001), acute bronchitis (BMI: OR=1.252, p <0.0001; WC: OR=1.237, p=0.000268), acute unspecified lower respiratory infection (BMI: OR=1.303, p=0.000403), chronic tonsils and adenoids diseases (BMI: OR=1.236, p <0.0001; WC: OR=1.178, p=0.000157), chronic laryngotracheitis and laryngitis (WC: OR=1.300, p=0.00785), COPD (BMI: OR=1.429, p <0.0001; WC: OR=1.591, p <0.0001), asthma (BMI: OR=1.358, p <0.0001; WC: OR=1.515, p <0.0001), necrotic and suppurative conditions of lower respiratory tract (WC: OR=1.405, p=0.0427), pleural effusion (BMI: OR=1.277, p=0.00225; WC: OR=1.561, p<0.0001), pleural plaque (BMI: OR=1.245, p=0.0312), other diseases of the respiratory system (BMI: OR=1.448, p <0.0001; WC: OR=1.590, p <0.0001), and non-small cell lung cancer (BMI: OR=1.262, p=0.00576; WC: OR=1.398, p=0.00181). This study also indicated that obesity decreases the possibility of bronchiectasis (BMI: OR=0.705; p=0.00200).
This study revealed that obesity increases the risk of the majority of respiratory diseases (including 20 of all 35 respiratory diseases) and that obesity decreases the risk of bronchiectasis.
目前尚无综合的孟德尔随机化研究集中于肥胖如何影响呼吸系统疾病。
体重指数（BMI）和腰围主要来自英国生物库，35 种呼吸系统疾病来自芬兰生物库，对这些数据进行了孟德尔随机化分析。本研究主要采用逆方差加权法进行分析，并辅以 MR-Egger 和加权中位数法。采用 MR-PRESSO 法检测水平多效性和潜在的异常值。
本研究表明，肥胖增加了急性上呼吸道感染（BMI：OR=1.131，p<0.0001；WC：OR=1.097，p=0.00406）、急性鼻窦炎（BMI：OR=1.161，p=0.000262；WC：OR=1.209，p=0.000263）、急性咽炎（WC：OR=1.238，p=0.0258）、急性喉炎和气管炎（BMI：OR=1.202，p=0.0288；WC：OR=1.381，p=0.00192）、所有流感（BMI：OR=1.243，p=0.000235；WC：OR=1.206，p=0.0119）、病毒性肺炎（WC：OR=1.446，p=0.000870）、所有肺炎（BMI：OR=1.174，p<0.0001；WC：OR=1.272，p<0.0001）、细菌性肺炎（BMI：OR=1.183，p=0.000290；WC：OR=1.274，p<0.0001）、急性支气管炎（BMI：OR=1.252，p<0.0001；WC：OR=1.237，p=0.000268）、急性未特指下呼吸道感染（BMI：OR=1.303，p=0.000403）、慢性扁桃体和腺样体疾病（BMI：OR=1.236，p<0.0001；WC：OR=1.178，p=0.000157）、慢性喉气管和喉炎（WC：OR=1.300，p=0.00785）、COPD（BMI：OR=1.429，p<0.0001；WC：OR=1.591，p<0.0001）、哮喘（BMI：OR=1.358，p<0.0001；WC：OR=1.515，p<0.0001）、下呼吸道坏死和化脓性疾病（WC：OR=1.405，p=0.0427）、胸腔积液（BMI：OR=1.277，p=0.00225；WC：OR=1.561，p<0.0001）、胸腔积块（BMI：OR=1.245，p=0.0312）、其他呼吸系统疾病（BMI：OR=1.448，p<0.0001；WC：OR=1.590，p<0.0001）和非小细胞肺癌（BMI：OR=1.262，p=0.00576；WC：OR=1.398，p=0.00181）。本研究还表明，肥胖降低了支气管扩张症的可能性（BMI：OR=0.705；p=0.00200）。
本研究揭示了肥胖增加了大多数呼吸系统疾病（包括 35 种呼吸系统疾病中的 20 种）的风险，而肥胖降低了支气管扩张症的风险。
