Michel F B, Guendon R, Guerrero A J
Nouv Presse Med. 1976 Sep 11;5(29):1811-4.
Numerous studies, based upon the frequency of allergic and auto-immune disorders in association with selective deficiency in IgA, as well as the abnormally high proportion of IgA deficiency in atopic patients, have led to the hypothesis that allergy results from a deficiency in IgA during the first months of life. Thus subjects with an initial transient deficiency in IgA (followed by normal or greater than average production) produce an excess of IgE. The aim of this study, carried out by multifactorial data analysis, was to determine whether serum IgE levels were related to those of IgA. Comparison of the serum Ig levels of 4 groups of individuals, with or without IgA deficiency, showed that the production of IgE was more closely related to the respiratory condition responsible than to IgA levels. According to IgA and E levels, the 4 groups differ distinctly, atopic patients without asthma constituting a "bridge" between the control group and those with asthma. In the presence of an apparently identical situation, i.e. an IgA deficiency, individuals may react in two different ways: some produce an abundance of IgE whilst others fail to do so and are more susceptible to recurrent infective episodes. The role of the genetic control of IgE as well as environmental factors in the pathogenesis of allergic manifestations is discussed.
基于与IgA选择性缺乏相关的过敏性和自身免疫性疾病的发生频率，以及特应性患者中IgA缺乏的比例异常高，众多研究提出了这样的假说：过敏是由于生命最初几个月IgA缺乏所致。因此，最初存在短暂性IgA缺乏（随后IgA产生正常或高于平均水平）的个体产生过量的IgE。本研究通过多因素数据分析进行，旨在确定血清IgE水平是否与IgA水平相关。对4组有或无IgA缺乏个体的血清Ig水平进行比较，结果显示IgE的产生与所患的呼吸道疾病关系更为密切，而非与IgA水平相关。根据IgA和IgE水平，这4组个体差异明显，无哮喘的特应性患者构成了对照组和哮喘患者之间的“桥梁”。在存在明显相同情况（即IgA缺乏）时，个体可能有两种不同的反应：一些人产生大量IgE，而另一些人则不产生，且更容易发生反复感染。本文还讨论了IgE的基因控制以及环境因素在过敏表现发病机制中的作用。
