Prevention Research Center, Pennsylvania State University, University Park, PA, USA; Society and Health Research Center and Facultad de Ciencias Sociales y Artes, Universidad Mayor, Santiago, Chile; Millennium Nucleus for the Evaluation and Analysis of Drug Policies (nDP), Chile.
Human Development and Family Studies, Pennsylvania State University, University Park, PA, USA.
Drug Alcohol Depend. 2023 Dec 1;253:111031. doi: 10.1016/j.drugalcdep.2023.111031. Epub 2023 Nov 18.
Adolescent nicotine exposure via electronic cigarettes (e-cigarettes) is a global health concern. Pubertal development earlier than peers increases the risk of tobacco smoking compared to peers experiencing on-time or late maturation, yet relationships of pubertal timing with e-cigarettes are unknown. We examine whether early pubertal timing is associated with risk for e-cigarette use, tobacco cigarettes, or both by age 14.
The Millennium Cohort Study follows a representative cohort of 18,552 9-month-old children born 2000-2002 in the United Kingdom. Our sample includes 11,445 adolescents (5697 boys, 5748 girls) classified at age 14 as early, on-time, or late in pubertal development timing (PDT) relative to same-age, same-sex peers using the Pubertal Development Scale. Outcomes were use of e-cigarettes, tobacco cigarettes, or both by age 14. We included childhood liability confounders and demographics measured from age 7-11.
For girls, no PDT differences in age 14 e-cigarette or tobacco cigarette use were observed. All relative to on-time PDT boys, early maturing boys' odds of tobacco cigarette use were 59% higher (OR=1.59, 95% confidence interval (CI)=1.08,2.35), and odds of dual-use were 49% higher (OR=1.49, CI=1.11,1.99), both compared to odds of never use. Among late PDT boys, dual-use odds were lower than never use by 35% (OR=0.65, CI=0.47,0.91) and lower than e-cigarette use only by 36% (OR=0.64, CI=0.42,0.97).
At age 14, PDT was not associated with e-cigarette use for either sex, yet it was linked with tobacco use and dual use among boys.
青少年通过电子烟摄入尼古丁是一个全球性的健康问题。与经历按时或延迟成熟的同龄人相比，青春期提前会增加吸烟的风险，但青春期与电子烟的关系尚不清楚。我们研究了青春期早期是否与 14 岁时使用电子烟、香烟或两者都有关。
千禧年队列研究跟踪了英国 2000-2002 年出生的 18552 名 9 个月大的儿童，他们组成了一个代表性的队列。我们的样本包括 11445 名青少年（5697 名男孩，5748 名女孩），他们在 14 岁时根据同龄同性别的青春期发育量表（Pubertal Development Scale）的评分，被分为青春期发育早、按时或晚。结果是在 14 岁时使用电子烟、香烟或两者都有。我们纳入了从 7 岁到 11 岁测量的儿童易感性混杂因素和人口统计学数据。
对于女孩，在 14 岁时使用电子烟或香烟的青春期发育时间上没有差异。与按时发育的男孩相比，所有青春期提前的男孩使用香烟的可能性都高出 59%（OR=1.59，95%置信区间（CI）=1.08，2.35），而双重使用的可能性高出 49%（OR=1.49，CI=1.11，1.99），这两种情况均高于从不使用的情况。在青春期发育晚的男孩中，双重使用的可能性比从不使用的可能性低 35%（OR=0.65，CI=0.47，0.91），比只使用电子烟的可能性低 36%（OR=0.64，CI=0.42，0.97）。
在 14 岁时，青春期发育与性别无关，但与男孩的吸烟和双重使用有关。
