Field Service London and South East, UK Health Security Agency, Nobel House, London, United Kingdom.
Department of Infection, Epsom and St Heliers' University Hospitals, Carshalton, United Kingdom.
J Infect. 2024 Jan;88(1):15-20. doi: 10.1016/j.jinf.2023.11.004. Epub 2023 Nov 21.
Campylobacter bacteraemia is a rare complication of the most common bacterial gastrointestinal infection but is associated with significant morbidity and mortality. There is limited data describing current trends in surveillance and antimicrobial resistance for the Campylobacter strains involved. At the Epsom and St Helier's University Hospital (ESTH), we noted a marked increase in Campylobacter bacteraemia infections in 2021.
We extracted Campylobacter reports using the UK Health Security Agency's (UKHSA) Second Generation Surveillance System (laboratory reporting system) between 1st January 2012 and 31st December 2021. We reviewed patient records of patients with Campylobacter bacteraemia for details including presentation, past medical history, duration of hospital stay, and antibiotic use.
Between 2012 and 2021, ESTH reported a total of 34 cases of Campylobacter bacteraemia. In 2021, the estimated incidence was 6.8 cases per 100,000 population and in the surrounding area, the incidence was 0.4 per 100,000 population. The incidence rate of Campylobacter bacteraemia in London and the South East region was significantly lower than ESTH (RR = 0.17, p < 0.0001). Campylobacter bacteraemia cases at ESTH reported a high number of co-morbidities (average number of comorbidities = 2.3) and had a duration of stay in hospital of a median of 7 days (IQR = 4-10 days). Campylobacter jejuni was the most commonly reported species for stool and blood Campylobacter in ESTH, London, and South East England.
Campylobacter bacteraemia reports at ESTH were significantly (p < 0.001) higher than the surrounding London and South East region. While no common cause for the exceedance of Campylobacter bacteraemia has been identified, common risk factors for Campylobacter bacteraemia infection include underlying health conditions, being older, and male.
弯曲菌菌血症是最常见的细菌性胃肠道感染的罕见并发症，但与显著的发病率和死亡率相关。目前关于弯曲菌菌株的监测和抗生素耐药性趋势的数据有限。在埃普索姆和圣赫利尔大学医院（ESTH），我们注意到 2021 年弯曲菌菌血症感染明显增加。
我们使用英国卫生安全局（UKHSA）第二代监测系统（实验室报告系统）提取 2012 年 1 月 1 日至 2021 年 12 月 31 日期间的弯曲菌报告。我们回顾了弯曲菌菌血症患者的病历，详细了解其就诊情况、既往病史、住院时间和抗生素使用情况。
在 2012 年至 2021 年期间，ESTH 共报告了 34 例弯曲菌菌血症。2021 年，估计发病率为每 10 万人中有 6.8 例，而周边地区的发病率为每 10 万人中有 0.4 例。ESTH 的弯曲菌菌血症发病率明显高于伦敦和东南地区（RR = 0.17，p < 0.0001）。ESTH 报告的弯曲菌菌血症病例合并症较多（平均合并症数为 2.3），住院时间中位数为 7 天（IQR = 4-10 天）。ESTH、伦敦和东南英格兰报告的粪便和血液弯曲菌中，最常见的物种是空肠弯曲菌。
ESTH 的弯曲菌菌血症报告明显高于周边的伦敦和东南地区（p < 0.001）。虽然尚未确定弯曲菌菌血症发生率超过的共同原因，但弯曲菌菌血症感染的常见危险因素包括潜在健康状况、年龄较大和男性。
