Kapnisis Dimitrios, Chatzigrigoriadis Christodoulos, Koufopoulos Emmanouil, Kolonitsiou Fevronia, Dimitriou Gabriel, Fouzas Sotirios, Eskitzis Panagiotis, Lavasidis Lazaros, Anestakis Doxakis, Sperdouli Despoina, Galiatsatos Panagis, Gkentzi Despoina
Department of Pediatrics, University General Hospital of Patras, Patras Medical School, Patras, Greece.
School of Medicine, University of Patras, Patras, Greece.
J Med Cases. 2025 Jun 16;16(6):201-211. doi: 10.14740/jmc5133. eCollection 2025 Jun.
Neonatal meningitis is associated with increased morbidity, mortality, and long-term consequences. Despite the use of newer techniques, the diagnosis remains challenging, especially in cases caused by rare pathogens. is widely known as the most common cause of bacterial gastroenteritis. However, invasive infections in neonates have been rarely described in the literature. A rare case of neonatal meningitis caused by is presented in this case report. A 14-day-old male and late preterm neonate without a remarkable perinatal history was admitted to our Pediatric Department with a 10-h history of fever and loose stools. The initial laboratory studies suggested the diagnosis of meningitis, but isolating the responsible pathogen in blood and cerebrospinal fluid cultures was demanding. After the cultures were repeated and incubated in microaerophilic conditions, was confirmed as the etiological agent. Based on antibiotic susceptibility tests, the neonate had a 21-day course of antibiotic therapy with cefotaxime, a third-generation cephalosporin, and remained healthy during the illness without experiencing any neurological sequelae. This case report highlights that rare pathogens should be considered and searched for in cases of neonatal meningitis when there is no identifiable cause with routine microbiological techniques.
新生儿脑膜炎与发病率、死亡率增加以及长期后果相关。尽管采用了更新的技术，但诊断仍然具有挑战性，尤其是在由罕见病原体引起的病例中。 广为人知是细菌性肠胃炎最常见的病因。然而，新生儿侵袭性感染在文献中很少被描述。本病例报告呈现了一例由 引起的罕见新生儿脑膜炎病例。一名14天大的晚期早产儿男性，围产期病史无异常，因发热和腹泻10小时入住我院儿科。初步实验室检查提示脑膜炎诊断，但在血液和脑脊液培养中分离出致病病原体颇具难度。在重复培养并在微需氧条件下孵育后， 被确认为病原体。根据抗生素敏感性试验，该新生儿接受了为期21天的头孢噻肟（第三代头孢菌素）抗生素治疗，患病期间保持健康，未出现任何神经后遗症。本病例报告强调，当常规微生物技术无法确定病因时，在新生儿脑膜炎病例中应考虑并寻找罕见病原体。
