Rezaei Fatemeh, Alinezhad Heshmatollah, Maleki Behrooz
Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
Sci Rep. 2023 Nov 23;13(1):20562. doi: 10.1038/s41598-023-47794-2.
Captopril (CAP) is a safe, cost-effective, and environmentally organic compound that can be used as an effective organo-catalyst. Functional groups of captopril make it capable to attach to solid support and acting as promoters in organic transformations. In this work, captopril was attached to the surface of magnetic graphene nitride by employing a linker agent. The synthesized composite efficiently catalyzed two multicomponent reactions including the synthesis of 1,2,3,6-tetrahydropyrimidine and 2-amino-4H-chromene derivatives. A large library of functional targeted products was synthesized in mild reaction conditions. More importantly, this catalyst was stable and magnetically recycled and reused for at least five runs without losing catalytic activity.
卡托普利（CAP）是一种安全、具有成本效益且环保的有机化合物，可用作有效的有机催化剂。卡托普利的官能团使其能够附着在固体载体上，并在有机转化中充当促进剂。在这项工作中，通过使用连接剂将卡托普利附着在磁性氮化石墨烯表面。合成的复合材料高效催化了两个多组分反应，包括1,2,3,6-四氢嘧啶和2-氨基-4H-色烯衍生物的合成。在温和的反应条件下合成了大量功能靶向产物。更重要的是，这种催化剂稳定且可通过磁性回收和重复使用至少五次而不丧失催化活性。
