颅骨骨髓通道作为免疫进入中枢神经系统的门户。
Skull bone marrow channels as immune gateways to the central nervous system.
机构信息
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA.
出版信息
Nat Neurosci. 2023 Dec;26(12):2052-2062. doi: 10.1038/s41593-023-01487-1. Epub 2023 Nov 23.
Abstract
Decades of research have characterized diverse immune cells surveilling the CNS. More recently, the discovery of osseous channels (so-called 'skull channels') connecting the meninges with the skull and vertebral bone marrow has revealed a new layer of complexity in our understanding of neuroimmune interactions. Here we discuss our current understanding of skull and vertebral bone marrow anatomy, its contribution of leukocytes to the meninges, and its surveillance of the CNS. We explore the role of this hematopoietic output on CNS health, focusing on the supply of immune cells during health and disease.
摘要
几十年来的研究已经描述了各种免疫细胞对中枢神经系统的监测。最近，人们发现了连接脑膜与颅骨和脊椎骨髓的骨质通道（所谓的“颅骨通道”），这揭示了我们对神经免疫相互作用理解的新复杂性。在这里，我们讨论了我们对颅骨和脊椎骨髓解剖结构的现有认识，它对脑膜白细胞的贡献，以及它对中枢神经系统的监测。我们探讨了这种造血输出对中枢神经系统健康的作用，重点关注健康和疾病期间免疫细胞的供应。
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