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脑脊液通过硬脑膜通道直接进入调节颅骨骨髓龛。

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels.

机构信息

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Nat Neurosci. 2022 May;25(5):555-560. doi: 10.1038/s41593-022-01029-1. Epub 2022 Mar 17.

DOI:10.1038/s41593-022-01029-1
PMID:35301477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9081158/
Abstract

It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura-skull channels, and CSF proteins signal onto diverse cell types within the niches. After spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that regulates CNS immune responses.

摘要

目前尚不清楚来自颅骨骨髓龛的免疫细胞是如何被招募到脑膜中的。在这里，我们报告称脑脊液（CSF）通过硬脑膜-颅骨通道进入颅骨骨髓，CSF 蛋白信号传递到龛内的各种细胞类型。脊髓损伤后，CSF 携带的信号促进骨髓中的髓样细胞生成和髓样细胞向脑膜迁移。这揭示了一种通过 CSF 进行 CNS-骨髓通讯的机制，该机制调节 CNS 的免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/9081158/fcf2d9df7a08/nihms-1774791-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/9081158/0fe540fb00aa/nihms-1774791-f0004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/9081158/74508baeb57e/nihms-1774791-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/9081158/5449a77ff8e8/nihms-1774791-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/9081158/ce2f4e2a3302/nihms-1774791-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/9081158/6aa31c55e8e8/nihms-1774791-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/9081158/f3df04cd09bf/nihms-1774791-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/9081158/7c57724e8cdf/nihms-1774791-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/9081158/42fa1984c555/nihms-1774791-f0002.jpg
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