Abraham A S, Rosenman D, Meshulam Z, Zion M, Eylath U
Am J Med. 1986 Dec;81(6):983-8. doi: 10.1016/0002-9343(86)90392-x.
Serum, lymphocyte, and erythrocyte potassium, magnesium, and calcium levels were measured in 215 patients during the five days following acute myocardial infarction. Serum potassium fell from 4.25 +/- 0.05 to 4.08 +/- 0.06 mmol/liter (p less than 0.001), magnesium from 0.93 +/- 0.01 to 0.85 +/- 0.01 mmol/liter (p less than 0.001), and calcium from 2.4 +/- 0.02 to 2.2 +/- 0.08 mmol/liter (p less than 0.001). Lymphocyte potassium increased from 18.1 +/- 1.5 to 51.6 +/- 4.3 pmol/100 cells (p less than 0.001) and magnesium from 2.0 +/- 0.1 to 8.2 +/- 0.8 pmol/100 cells (p less than 0.001), whereas calcium decreased from 2.9 +/- 0.27 to 1.4 +/- 0.25 pmol/100 cells (p less than 0.001). Erythrocyte cations remained constant. There was a larger increase in lymphocyte potassium in patients with tachyarrhythmias than in patients without (70.4 and 46.9 pmol/100 cells, respectively, p less than 0.001), whereas the presence of a high lymphocyte magnesium level was associated with a significant decrease in the development of tachyarrhythmias, despite high potassium concentrations. It is suggested that lymphocyte cation concentrations mirror myocardial interstitial concentrations and that a high interstitial magnesium level has a protective effect on the increased cell excitability due to, and despite, a high interstitial potassium level.
在215例急性心肌梗死后的五天内，测量了其血清、淋巴细胞和红细胞中的钾、镁和钙水平。血清钾从4.25±0.05降至4.08±0.06 mmol/升（p<0.001），镁从0.93±0.01降至0.85±0.01 mmol/升（p<0.001），钙从2.4±0.02降至2.2±0.08 mmol/升（p<0.001）。淋巴细胞钾从18.1±1.5升至51.6±4.3 pmol/100细胞（p<0.001），镁从2.0±0.1升至8.2±0.8 pmol/100细胞（p<0.001），而钙从2.9±0.27降至1.4±0.25 pmol/100细胞（p<0.001）。红细胞阳离子保持不变。与无快速心律失常的患者相比，有快速心律失常的患者淋巴细胞钾升高幅度更大（分别为70.4和46.9 pmol/100细胞，p<0.001），而尽管钾浓度较高，但淋巴细胞镁水平较高与快速心律失常的发生显著减少有关。提示淋巴细胞阳离子浓度反映心肌间质浓度，高间质镁水平对因高间质钾水平导致的细胞兴奋性增加具有保护作用。
