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进行性核上性麻痹:一例伴有斜颈、眼睑痉挛和言语不流畅的病例报告。

Progressive supranuclear palsy: report of a case with torticollis, blepharospasm, and dysfluency.

作者信息

Janati A

出版信息

Am J Med Sci. 1986 Dec;292(6):391-2. doi: 10.1097/00000441-198612000-00011.

Abstract

A 76-year-old man is reported with advanced progressive supranuclear palsy (PSP) who developed a persistent, gradually progressive torticollis over a period of several months. Blepharospasm and dysfluency of the extrapyramidal type antedated the torticollis. This first report of torticollis in PSP reinforces previous notions that torticollis is related to pathologic changes in the striatum and brainstem. In addition, the combination of torticollis and blepharospasm in our patient supports the previous concept that these two "focal dystonias" have a common pathophysiologic mechanism. This also suggests that dysfluency in PSP may be an expression of a focal dystonia involving the muscles of articulation.

摘要

据报道,一名76岁男性患有晚期进行性核上性麻痹(PSP),在几个月的时间里出现了持续性、逐渐进展的斜颈。眼睑痉挛和锥体外系型言语不流畅先于斜颈出现。PSP中斜颈的这一首次报道强化了先前的观点,即斜颈与纹状体和脑干的病理变化有关。此外,我们患者中斜颈和眼睑痉挛的组合支持了先前的概念,即这两种“局灶性肌张力障碍”具有共同的病理生理机制。这也表明PSP中的言语不流畅可能是涉及发音肌肉的局灶性肌张力障碍的一种表现。

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