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Identification of 3'-terminal 2'-O-methylated miRNA in plasma as a novel diagnostic biomarker of NSCLC.

作者信息

Guo Xu, Guo Hongyuan, Lu Kuan-Chen, Yan Xin, Chen Jiehao, Wei Yanting, Han Jiayi, Sun Wu, Hu Huanhuan, Su Yuanyuan, Shen Lingyan, Zhang Yujing, Yin Kai, Zhang Chen-Yu, Fu Zheng

机构信息

Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences, Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.

Department of Vascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.

出版信息

Clin Transl Med. 2023 Nov;13(11):e1454. doi: 10.1002/ctm2.1454.

DOI:10.1002/ctm2.1454
PMID:37997565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10667623/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2a2/10667623/2016fd54e813/CTM2-13-e1454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2a2/10667623/060a22758480/CTM2-13-e1454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2a2/10667623/51f68efcb880/CTM2-13-e1454-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2a2/10667623/2016fd54e813/CTM2-13-e1454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2a2/10667623/060a22758480/CTM2-13-e1454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2a2/10667623/51f68efcb880/CTM2-13-e1454-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2a2/10667623/2016fd54e813/CTM2-13-e1454-g001.jpg

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本文引用的文献

1
Accurate quantification of 3'-terminal 2'-O-methylated small RNAs by utilizing oxidative deep sequencing and stem-loop RT-qPCR.利用氧化深度测序和茎环逆转录定量PCR对3'-末端2'-O-甲基化小RNA进行准确定量
Front Med. 2022 Apr;16(2):240-250. doi: 10.1007/s11684-021-0909-7. Epub 2022 Apr 13.
2
3'-Terminal 2'-O-methylation of lung cancer miR-21-5p enhances its stability and association with Argonaute 2.肺癌 miR-21-5p 的 3’端 2’-O-甲基化增强其稳定性并与 Argonaute 2 结合。
Nucleic Acids Res. 2020 Jul 27;48(13):7027-7040. doi: 10.1093/nar/gkaa504.
3
Direct quantification of 3' terminal 2'--methylation of small RNAs by RT-qPCR.
通过 RT-qPCR 直接定量小 RNA 的 3'末端 2'--甲基化。
RNA. 2018 Nov;24(11):1520-1529. doi: 10.1261/rna.065144.117. Epub 2018 Aug 3.
4
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA.外源性植物 MIR168a 特异性靶向哺乳动物 LDLRAP1：microRNA 跨物种调控的证据。
Cell Res. 2012 Jan;22(1):107-26. doi: 10.1038/cr.2011.158. Epub 2011 Sep 20.
5
Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma.血清 microRNA 谱可作为 HBV 感染和 HBV 阳性肝癌诊断的新型生物标志物。
Cancer Res. 2010 Dec 1;70(23):9798-807. doi: 10.1158/0008-5472.CAN-10-1001. Epub 2010 Nov 23.
6
The use of hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma.hsa-miR-21、hsa-miR-181b 和 hsa-miR-106a 作为星形细胞瘤预后指标的应用。
Eur J Cancer. 2010 Jun;46(9):1640-9. doi: 10.1016/j.ejca.2010.02.003. Epub 2010 Mar 8.
7
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases.血清中微小RNA的特征：用于癌症和其他疾病诊断的一类新型生物标志物。
Cell Res. 2008 Oct;18(10):997-1006. doi: 10.1038/cr.2008.282.
8
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.散发性阿尔茨海默病中微小RNA簇miR-29a/b-1的缺失与β-分泌酶1（BACE1）表达增加相关。
Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6415-20. doi: 10.1073/pnas.0710263105. Epub 2008 Apr 23.
9
The 3' termini of mouse Piwi-interacting RNAs are 2'-O-methylated.小鼠Piwi相互作用RNA的3'末端发生了2'-O-甲基化修饰。
Nat Struct Mol Biol. 2007 Apr;14(4):349-50. doi: 10.1038/nsmb1220. Epub 2007 Mar 25.
10
Methylation as a crucial step in plant microRNA biogenesis.甲基化作为植物微小RNA生物合成中的关键步骤。
Science. 2005 Feb 11;307(5711):932-5. doi: 10.1126/science.1107130.